Joshua Dubland
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Biography
Dr. Joshua Dubland is a laboratory scientist and clinical assistant professor in the Department of Pathology and Laboratory Medicine at BC Children's Hospital, UBC. Dr. Dubland completed his BSc in chemistry at Simon Fraser University, followed by an MSc in organic chemistry at the University of Toronto. He was then a research associate in the pharmaceutical industry for 4 years, working at both BRI Biopharmaceutical Research Inc. and QLT Inc. Work in the pharmaceutical industry focused on bioanalytical mass spectrometry development, validation, and data acquisition to support clinical and preclinical drug trials. Following this, Dr. Dubland completed his PhD in Experimental Medicine at UBC where his research focused on cellular mechanisms of lipid accumulation and removal in atherosclerosis. Dr. Dubland is currently located in the Newborn Screening and Biochemical Genetics Laboratory at BC Children's Hospital where his current research interests focus on the development of novel mass spectrometry-based assays for clinical diagnosis of inborn errors of metabolism. Additional research interests include applications of mass spectrometry and other next generation analytical technologies for biomarker and drug target discovery. Investigation of inherited lipid metabolism disorders, lysosomal storage disorders, and environmental stress factors associated with lifetime cardiovascular disease risk are of particular interest.
Research Methodology
Publications
- Editorial commentary: Role of inflammatory cytokines in genesis and treatment of atherosclerosis. Looking at foam cells through a different lens (2022)
Trends in Cardiovascular Medicine, - Lipid analysis by ion mobility spectrometry combined with mass spectrometry: A brief update with a perspective on applications in the clinical laboratory (2022)
Journal of Mass Spectrometry and Advances in the Clinical Lab, 23, 7--13 - Analysis of 2-methylcitric acid, methylmalonic acid, and total homocysteine in dried blood spots by LC-MS/MS for application in the newborn screening laboratory: A dual derivatization approach. (2021)
Journal of mass spectrometry and advances in the clinical lab, - Interference of ketone bodies on laboratory creatinine measurement in children with DKA: a call for change in testing practices. (2021)
Pediatric nephrology (Berlin, Germany), - Low LAL (Lysosomal Acid Lipase) Expression by Smooth Muscle Cells Relative to Macrophages as a Mechanism for Arterial Foam Cell Formation (2021)
Arteriosclerosis, Thrombosis, and Vascular Biology, 41 (6) - Pathways of smooth muscle foam cell formation in atherosclerosis. (2019)
Current opinion in lipidology, - Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis. (2019)
Arteriosclerosis, thrombosis, and vascular biology, - LAL (Lysosomal Acid Lipase) Promotes Reverse Cholesterol Transport In Vitro and In Vivo. (2018)
Arteriosclerosis, thrombosis, and vascular biology, - Lamivudine, Entecavir, or Tenofovir Treatment of Hepatitis B Infection: Effects on Calcium, Phosphate, FGF23 and Indicators of Bone Metabolism. (2017)
Annals of hepatology, - Randomized Controlled Trial for the Effect of Vitamin D Supplementation on Vascular Stiffness in CKD. (2017)
Clinical journal of the American Society of Nephrology : CJASN, - So Much Cholesterol: the unrecognized importance of smooth muscle cells in atherosclerotic foam cell formation. (2016)
Current opinion in lipidology, - Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism. (2015)
Frontiers in cell and developmental biology, - Determination of serum aldosterone by liquid chromatography and tandem mass spectrometry: a liquid–liquid extraction method for the ABSCIEX API-5000 mass spectrometry system (2012)
Journal of Clinical Pathology, - Carbon–carbon bond-forming reactions of α-carbonyl carbocations: exploration of a reversed-polarity equivalent of enolate chemistry (2011)
Tetrahedron, - Serum-protein interactions with anticancer Ru(III) complexes KP1019 and KP418 characterized by EPR. (2009)
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry,
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