Gabriela Segat
Postdoctoral Fellow
Using multiomics, flow cytometry, and functional studies, I discovered a T-cell acute lymphoblastic leukemia (T-ALL) subtype dependent on MYCN. Building upon preliminary results that suggest an important role of H3K4 methylation in controlling MYCN gene expression in these leukemias, my present research seeks to identify the key epigenetic modifiers responsible for establishing or maintaining H3K4 methylation in the context of T-ALL development. Ultimately, this investigation may unveil novel pharmacological targets for better combating specific subtypes of T-ALL.
Supervisor
Research Classification
Research Interests
Hematology
oncology
Inflammation
Epigenetics
Research Methodology
RNA-seq
ChIP-seq
High-parameter Flow Cytometry
primary cell culture
Human Synthetic T-ALL model
in-vivo testing
Research Centres, Clusters, Institutes
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
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