The Centre for Heart Lung Innovation (HLI) housed within Providence Health Care's St. Paul's Hospital in the heart of downtown Vancouver, British Columbia, Canada. The HLI (previously the James Hogg Research Centre) is a University of British Columbia (UBC) Senate-approved centre of cardiovascular, pulmonary, and critical care expertise.
Our research activities and programs have grown rapidly since the establishment of the fledgling pulmonary laboratory in 1977 when Dr. Jim Hogg, along with Dr. Peter Paré and Lisa Baile were recruited to St. Paul's Hospital to open the Pulmonary Research Laboratory. Expansion of the focus to include cardiovascular and critical care research occurred in the late 1980’s and early 1990’s with the recruitment of Drs. Mike Allard, Keith Walley, Jim Russell, and Bruce McManus. The growing laboratory was renamed the McDonald Research Laboratories (MRL) when the Cardiovascular Research Laboratory (1993) and the Atherosclerosis Specialty Laboratories (1995) joined the research environment.
Campus
Vancouver
Affiliated UBC Faculty & Postdocs
| Name | Role | Research Interests |
|---|---|---|
| Allard, Michael | Faculty (G+PS eligible/member) | Control of energy metabolism in normal and pathologic hearts; Physiologic and Pathologic Cardiac hypertrophy; Contribution of Metabolism to myocardial dysfunction after ischemia and reperfusion, especially in the setting of cardiac hypertrophy; Cardiovascular Pathology |
| Bernatchez, Pascal | Faculty (G+PS eligible/member) | Pharmacology and pharmaceutical sciences (except clinical aspects); Cardiovascular diseases; Cardiovascular System; Genetic Diseases; Hypertension; atherosclerosis; angiogenesis; Muscular Diseases; Neuromuscular Diseases; Lipid/Lipoprotein analysis; Lipid Disorders; Pharmacokinetics; Cell Signaling and Infectious and Immune Diseases; endothelial dysfunction; endothelium; Inflammation; lipoproteins; Marfan syndrome; muscular dystrophy; nitric oxide; vascular disease |
| Brunham, Liam | Faculty (G+PS eligible/member) | Medical, health and life sciences; Lipids; Genetics; Pharmacogenomics; Cardiovascular diseases |
| Carlsten, Christopher | Faculty (G+PS eligible/member) | Environment and Respiratory Diseases |
| Daley, Denise | Faculty (G+PS eligible/member) | Bioinformatics; Asthma; Complex Trait Genetics; Epigenetics; gene-gene and gene-environment interactions; Genetic Diseases; genetic epidemiology; Genetics of Aging; statistical genetics; Susceptibility Genes |
| Francis, Gordon | Faculty (G+PS eligible/member) | lipoproteins; Cholesterol metabolism; Cardiovascular risk factors; Prevention of cardiovascular disease and diabetes; High density lipoproteins (HDL) |
| Gray, Briony | Faculty (non-G+PS member) | |
| Guenette, Jordan | Faculty (G+PS eligible/member) | Respiratory diseases; Other biological sciences; Clinical exercise physiology; Cardiorespiratory physiology; Mechanisms and management of breathlessness and exercise intolerance; Chronic respiratory diseases |
| Hacihaliloglu, Ilker | Faculty (G+PS eligible/member) | Bio-signal processing and analysis; Medical biotechnology; Biomedical signal processing; Image guided surgery systems; Medical and biomedical engineering, n.e.c.; Data analytics and signal processing, n.e.c.; Artificial intelligence (AI); Extraction of relevant information from 3D medical images; Image Guided Surgery; computer assisted diagnosis; Deep Learning; point of care ultrasound; ultrasound image processing; Brain Health; orthopedic surgery; liver disease; lung disease; traumatic Brian injury; neurosurgery; Biomedical Engineering |
| Hackett, Tillie-Louise | Faculty (G+PS eligible/member) | Molecular determinants of COPD, small airway obstruction, angiotensin signalling, defective airway epithelial differentiation in asthma, human lung cell repository |
| Krahn, Andrew | Faculty (G+PS eligible/member) | management of cardiac arrhythmias; investigation of genetic causes of arrhythmias, causes of loss of consciousness and implantable arrhythmia device monitoring |
| Leipsic, Jonathon | Faculty (G+PS eligible/member) | Diagnostic performance and radiation reduction as well as CT to guide minimally invasive valve intervention |
| Luo, Honglin | Faculty (G+PS eligible/member) | Basic medicine and life sciences; Viral Infections; Cardiomyopathy; Innate immunity; Central Nervous System Inflammatory Diseases; Enteroviral infection and neurodegeneration; Oncolytic virus; Protein quality control in cardiac remodeling; RNA viruses |
| McNagny, Kelly Marshall | Faculty (G+PS eligible/member) | Cellular immunology; Regenerative medicine (including stem cells and tissue engineering); Stem Cells; Immunology; Inflammation; Mouse models of human disease; Tissue degeneration/regeneration; Cancer; innate immune response; kidney function; Biologics and therapeutics |
| Ng, Raymond Tak-yan | Faculty (G+PS eligible/member) | Data mining and analysis, health informatics, text summarization, text mining |
| Quon, Bradley | Faculty (G+PS eligible/member) | Cystic Fibrosis; Epidemiology; Respiratory System; Proteomics; Immune Mediators: Cytokines and Chemokines; biomarker discovery and development; clinical epidemiology; health care economics; medication adherence |
| Russell, James | Faculty (G+PS eligible/member) | old world, Iron Age, Celtic, classical Greek, Roman and Byzantine art, archaeology, architecture, ancient Roman daily life and culture;Roman military organization early Christianity; magic in antiquity; Greek and Roman inscriptions and coins; Scottish and Irish archaeology; old world and classical architecture, archaeology and culture with emphasis on Western Europe and Middle East; Celtic (especially Ireland and Scotland); Greek and Roman, classical and Byzantine; Latin, Greek, Lallans and lowland Scots; Scottish literature; Robert Burns; Scottish poetry generally; ancient through early Islam, especially Turkey; Eastern Europe, New therapy for sepsis (severe infection), septic shock and acute lung injury, role of genetics of the inflammatory response in the critically ill |
| Ryerson, Christopher | Faculty (G+PS eligible/member) | Interstitial lung disease, idiopathic pulmonary fibrosis, combined pulmonary fibrosis and emphysema, dyspnea, pulmonary rehabilitation, symptom management, health care databases. |
| Sadatsafavi, Mohsen | Faculty (G+PS eligible/member) | Respiratory diseases; Epidemiology (except nutritional and veterinary epidemiology); Epidemiology; Biostatistics; Respiratory Research |
| Sandford, Andrew | Faculty (G+PS eligible/member) | genetic basis of asthma and has extended his studies to include the genetics of chronic obstructive pulmonary disease (COPD) and peanut allergy as well as the genetic basis of pulmonary disease severity in cystic fibrosis; potential effects on gene function of genetic variants associated with these disease outcomes |
| Sin, Donald | Faculty (G+PS eligible/member) | CODP (Chronic Obstructive Pulmonary Disease) |
| Tebbutt, Scott | Faculty (G+PS eligible/member) | Basic medicine and life sciences; Dual organism molecular interaction (fungal spores & human airway epithelium); Early and late reactions in allergic asthma and rhinitis; Diagnostics of acute heart rejection post-transplantation; Neonatal vaccine immunogenicity; Systems biology, biomarkers & bioinformatics; Rheumatic fever and heart disease; COVID-19 |
| Wang, Ying | Faculty (G+PS eligible/member) | Cardiology and circulatory sciences (including cardiovascular disease); Cell differentiation, proliferation and death; Drug discovery, design and delivery; atherosclerosis; Diabetic cardiomyopathy; Vascular biology; Spatial 'Omics'; Drug repurposing and therapeutic design; Disease modeling; Digital Pathology |
| Yao, Yuan | Faculty (G+PS eligible/member) | Biomaterial manufacturing and engineering; Nano/microfabrication and 3D bioprinting; Tissue engineering and organ regeneration; Therapeutic strategies for cardiovascular disease |