Maryam Vaseghi-Shanjani
Doctor of Medicine and Doctor of Philosophy (MDPhD)
Research Topic
Discovery and characterization of novel primary immunodeficiency diseases in humans
Stuart Turvey
Professor
Research Classification
Research Interests
Asthma
Immune System
Immunodeficiencies
Microbiome cohort studies
Precision Medicine
Primary Immune Deficiencies
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Biography
Stuart Turvey, MBBS, DPhil, FRCPC is a Professor of Pediatrics at the University of British Columbia where he holds both the Tier 1 Canada Research Chair in Pediatric Precision Health and the Aubrey J. Tingle Professorship in Pediatric Immunology. He is a Pediatric Immunologist based at BC Children’s Hospital, and Director of Clinical Research at the Child & Family Research Institute. Prior to coming to Vancouver, Dr Turvey completed both his Pediatric Residency and Allergy/Immunology Fellowship at Children’s Hospital, Harvard Medical School, Boston. He holds a medical degree (MB BS) from the University of Sydney, Australia and a doctorate (DPhil) in Immunology from Oxford University where he was a Rhodes Scholar. Dr Turvey is a Fellow of the Royal College of Physicians and Surgeons of Canada and a Diplomate of the American Board of Pediatrics.
Dr Turvey provides clinical care in the specialty of Clinical Immunology, while his research program focuses on pediatric infectious and inflammatory diseases.
RESEARCH AREAS
• Innate immunity
• Host defense
• Primary immunodeficiency diseases (PIDs)
• Role of Toll-like receptors in human disease
• Airway inflammation in cystic fibrosis
• Asthma and allergic disease
• Microbiome in health and disease
RESEARCH PROGRAM
Despite much effort, we know little about how the healthy child is protected from infectious disease, and even less about why some children develop inflammatory disorders. Why do some healthy children succumb to overwhelming bacterial infection, while others either survive infection or do not become infected at all? Why do some children suffer crippling juvenile arthritis or life-threatening asthma?
My research program is translational, interdisciplinary and unique in its focus on understanding the role of innate immunity in infectious and inflammatory diseases of childhood. Starting with a population of children with a defined infectious or inflammatory disease phenotype (e.g., undue susceptibility to infection, juvenile idiopathic arthritis, asthma), I aim to determine the underlying cellular, molecular and genetic abnormalities responsible for the disease through detailed immunological, genomic and proteomic analysis. The new knowledge generated by this approach will aid diagnosis, elucidate mechanisms of disease pathogenesis and, ultimately, identify novel targets for anti-inflammatory and anti-infectious therapeutic agents.
Recruitment
Master's students
Doctoral students
Postdoctoral Fellows
Any time / year round
Genetics of Susceptibility to Childhood Infection Until very recently, clinical immunologists have focused most attention on patients with a ‘noisy clinical phenotype’—multiple, severe and recurrent infections. Indeed, the origin of primary immunodeficiencies is generally attributed to Bruton’s 1952 description of X-linked agammaglobulinemia in a boy whose repeated pneumococcal infections demanded clinical attention. Today, enhanced understanding of human immunity combined with ever more sophisticated tools to dissect the immune response have allowed clinical immunologists to look beyond these "noisy", severely immunocompromised patients to individuals with less obvious immune defects. We have entered the era of "subtle" primary immunodeficiencies that will begin to precipitate a fundamental change and expansion of the focus of clinical immunologists. My lab is involved in searching for subtle genetic immune defects in apparently healthy children who have serious immunological disorders. This journey towards subtlety is anticipated to translate into better care for our patients through improved diagnosis, combined with tailored treatment and targeted prophylaxis. Canadian Healthy Infant Longitudinal Development (CHILD) Study Over the past 30 years there has been an increasing concern about the effects of environment on health. In particular, since infants spend the majority of their time indoors, there is intense interest in the impact indoor pollution has on the health of our children. Our indoor environment has become a public health priority as growing evidence suggests that unseen environmental contaminants in our living spaces may have important effects on children's health and development. The Canadian Healthy Infant Longitudinal Development (CHILD) Study is a multicentre, multidisciplinary, longitudinal, population-based birth-cohort study of 5,000 children enrolled "pre-birth" and followed for five years (www.canadianchildstudy.ca). The main purpose of this study is to determine what aspects of the environment interact with genetic factors to affect children’s health and development. I am a co-principal investigator for the CHILD study and I lead the Vancouver study site. Innate Immunity and Lung Inflammation in Cystic Fibrosis Cystic fibrosis (CF) is the most common, deadly genetic disease affecting young Canadians. Even today, only half of the people living with CF will survive beyond their mid-thirties. New treatments for CF are critically needed. Lung disease is the major life-limiting factor for people living with CF. Lung injury in CF occurs through a vicious cycle of airway blockage, infection and inflammation. Current CF treatments rely upon physiotherapy to reduce airway blockage and antibiotics to treat the infections, but these treatments do not specifically deal with inflammation. New treatments to simultaneously target airway inflammation are likely to provide substantial additional benefits in improving the quality and length of life for those with CF. Through synergistic studies harnessing the power of cell biology, chemistry and functional genomics, we are working to identify optimal "druggable" targets responsible for CF airway inflammation and to discover novel anti-inflammatory drugs. Ultimately, these experiments are designed to develop new therapies for safely reducing lung inflammation and improving the quality and length of life of people with CF.
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Graduate Student Supervision
Doctoral Student Supervision
Dissertations completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest dissertations.
Defining the functional impact of three new human primary immune regulatory disorders caused by defects in genes NFATC2, STAT6 and OSMR (2022)
The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.
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Defining the pathogenesis of human inborn errors of immunity affecting the CARD11-BCL10-MALT1 complex (2021)
Primary immunodeficiency diseases or inborn errors of immunity are a group of rare genetic disorders in which key elements of the immune system are absent or dysfunctional. This typically manifests as greatly enhanced susceptibility to infection, autoimmunity, autoinflammation, malignancy, and/or atopy. Studying these patients can be very informative as they provide a rare opportunity to uncover the fundamental role of single genes in human immunity and disease, which can inform the development of targeted precision therapeutics and patient treatment.Germline mutations affecting caspase recruitment domain (CARD)—B cell CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1) [CBM] complexes or ‘CBM-opathies’ have recently been linked to a broad spectrum of diseases, including invasive fungal disease, lymphoproliferation, severe atopic disease, psoriatic skin diseases, and profound combined immunodeficiency. These disorders can be difficult to diagnose as their (i) pathogenesis is incompletely understood; (ii) phenotypes are heterogeneous and can be similar to other PIDs; and (iii) incidence is low. With increased use of diagnostic next generation sequencing (NGS) in the clinic, a large number of variants of uncertain significance have been identified in these genes, further complicating diagnosis. The research presented in this thesis was focused on advancing the diagnosis, understanding, and treatment of germline CBM-opathies. We accomplished this by collecting and reporting all known clinical parameters from patients with germline mutations affecting CBM complexes and classified/unified these under the new term ‘CBM-opathies.’ Furthermore, we performed NGS on various patients with combined immunodeficiency, designed assays to functionally validate the pathogenicity of identified variants, and translated our findings into clinical care. Through this work, we were able to (i) classify the pathogenicity of four novel variations of CARD11; (ii) define the role of CARD11 in human B cell development, signalling, and function; (iii) and uncover the role of MALT1 paracaspase activity in mediating the pathogenesis of B cell Expansion with NF-кB and T cell Anergy (BENTA) disease.
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Defining the role of the human intestinal microbiota in childhood asthma and atopic disease (2017)
Asthma is a chronic inflammatory atopic disease of the airways affecting one in ten children in Westernized countries. The microflora hypothesis of allergic disease proposes the intestinal microbiota as a potential mechanistic link connecting environmental exposures to changes in the developing immune system. Further, animal model studies allude to an early life critical window, during which the immune system is most vulnerable to compositional and functional changes in the intestinal microbiota.We conducted an epidemiological assessment of early life environmental factors associated with atopy and wheezing at age 1 year and preschool-age asthma in children enrolled in the Canadian Healthy Infant Longitudinal Development (CHILD) Study (n = 2,695). Here, we identified early life microflora hypothesis related variables (e.g. pre- and post-natal antibiotic exposure, gestational age, and birth mode) as risk and protective factors for asthma and atopic disease. Informed by this epidemiological assessment, we used 16S ribosomal RNA sequencing and quantitative polymerase chain reaction to analyze the 3-month and 1-year fecal microbiota of one-year-old CHILD Study subjects positive or negative for atopy and wheezing (n = 319) and among this same cohort, those who were diagnosed with preschool-age asthma or non-atopic non-wheezing controls (n = 76). The fecal microbiota of atopic wheezing subjects compared to controls showed decreases in the abundances of four gut bacterial genera, Faecalibacterium, Lachnospira, Rothia, and Veillonella, combined with a reduction in fecal acetate at the 3-month time point only. Further, we found shifts in the relative abundances of two bacterial taxa in the 3-month fecal microbiota of preschool-age asthmatic children compared to controls; Lachnospira remained decreased among asthmatic children and Clostridium neonatale was increased in asthmatics. Quartile analysis at 3-months revealed a negative association between the ratio of these two bacteria (Lachnospira/Clostridium neonatale) and asthma risk. Altogether, this research highlights environmental factors that may be contributing to gut bacterial alterations in subjects with asthma or atopic disease. Additionally, these microbial alterations were no longer present by 1-year of age, suggesting the first 100 days of life as the critical window during which taxa-specific gut bacterial dysbiosis is associated with asthma and atopic disease in humans.
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Genetic association and gene expression analysis of inflammatory genes in cystic fibrosis (2016)
Cystic fibrosis (CF) is characterized by a progressive decline in lung function due to airway obstruction, infection, and inflammation. CF patients are particularly susceptible to respiratory infection by a variety of pathogens, and the inflammatory response in CF is dysregulated and prolonged. This thesis identifies and characterizes BPI fold containing family A, member 1 (BPIFA1) and BPIFB1 as putative anti-inflammatory molecules in CF, and explores the CF inflammatory response to rhinovirus infection. BPIFA1 and BPIFB1 are proposed innate immune molecules expressed in the upper airways. We interrogated BPIFA1/BPIFB1 single-nucleotide polymorphisms in data from the North American genome-wide association study (GWAS) for lung disease severity in CF and discovered that the G allele of rs1078761 was associated with reduced lung function in CF patients. Microarray and qPCR gene expression analysis implicated rs1078761 G as being associated with reduced BPIFA1 and BPIFB1 gene expression, suggesting that decreased levels of these genes are detrimental in CF.Functional assays to characterize the role of BPIFA1 and BPIFB1 in CF indicated that these molecules do not have an anti-bacterial role against P. aeruginosa, but do have an immunomodulatory function in CF airway epithelial cells. To further investigate the mechanism of action of BPIFA1 and BPIFB1 during bacterial infection, gene expression was profiled using RNA-Seq in airway epithelial cells stimulated with P. aeruginosa and treated with recombinant BPIFA1 and BPIFB1.Viral infections are now recognized to play an important role in the short and long term health of CF patients. Rhinovirus is emerging as a lead viral pathogen although little is known about the inflammatory response triggered by rhinovirus in the CF lung. To investigate whether CF patients have a dysregulated response to rhinovirus infection, primary airway epithelial cells from CF and healthy control children were infected with rhinovirus and gene expression profiles were assessed by RNA-Seq. Although rhinovirus stimulation resulted significantly altered gene expression, the response to infection was not different in CF patients compared to healthy controls. However, CF cells had significantly higher rhinovirus levels than controls, indicating that CF patients may have a deficient antiviral response allowing for increased rhinovirus replication.
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The role of endoplasmic reticulum stress and inflammasome activation in inflammatory disease: identifying therapeutic targets in cystic fibrosis and haematological malignancies (2016)
An increasing number of infectious and inflammatory conditions have identified ER stress and IL-1β as central driving forces in inflammation. In the following studies, we have identified several important pathways that promote the cycle of pulmonary inflammation in cystic fibrosis (CF), including the IL-1β regulation by NF-κB, IL-1β stimulation of neutrophil chemokine production by airway epithelial cells, and inhibition of neutrophil chemokine secretion through ER stress signaling. Based on our observations, we conclude that CF environmental factors such as increased NF-κB priming by chronic infection and the presence of ER stressors can significantly augment inflammatory responses by controlling the maturation of IL-1β. These effects appear to be cell type and cytokine-specific, as downstream induction of CXCL1 and IL-8, key neutrophil chemokines that we found were associated with lung disease severity in CF patients, can also be suppressed by ER stress-mediated inhibition of STAT3 signaling in airway epithelial cells.Interestingly, we also found that by varying the time of TLR stimulation relative to the induction of ER stress (particularly by proteasome inhibition), we could obtain differential effects on IL-1β production and maturation. We reasoned that these effects could be important in haematological malignancies where proteasome inhibition has recently become a successful first-line treatment. Not only was tumour cell cytotoxicity significantly increased by addition of a TLR adjuvant, IL-1β production could be controlled depending on when the adjuvant was added relative to the proteasome inhibitor. This could be a useful method in which IL-1β-mediated responses can be manipulated while also increasing tumour cell death.
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Innate immunity and inflammation in Cystic Fibrosis lung disease (2011)
No abstract available.
Master's Student Supervision
Theses completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest theses.
Functional and biochemical characterization of novel genetic variants in IRAK4 and IRF4 causing human inborn errors of immunity (2021)
Human inborn errors of immunity (IEIs) are a group of genetic disorders in which specific components of the human immune system are missing, dysfunctional, or poorly regulated. IEIs negatively impact the protective functions of the immune system, increasing susceptibility to infections, autoimmunity, inflammation, and malignancy. The investigation of monogenic IEIs enables the diagnosis and treatment of the affected individuals and provides unique opportunities to understand the role of the immune system and the functional roles of its constituents.Toll-like receptor (TLR) signaling is a key aspect of the innate immune response, and interleukin-1 receptor-associated kinase 4 (IRAK4) plays a vital role in the TLR signaling cascade which enables the production of protective inflammatory cytokines. Human IRAK4-deficiency is an autosomal recessive IEI which presents with a blunted inflammatory response to infection and susceptibility to certain bacteria. We demonstrate that the novel IRAK4 (c.1049delG, p.(Gly350Glufs*15)) variant abrogates IRAK4 protein expression and abolishes TLR signaling, expanding the knowledge of pathogenic variants causing human IRAK4-deficiency.We have also identified 3 unrelated individuals with a phenotype of combined immunodeficiency (agammaglobulinemia and infectious susceptibility) who carry a novel heterozygous de novo missense variant in Interferon Regulatory Factor 4 (IRF4) gene (c.284C>G, p.T95R). IRF4 is a transcription factor expressed in immune cells which plays a critical role in the differentiation of various immune cells. We demonstrate adaptive immune cell differentiation defects in proband primary cells, as well as decreased effector cytokine production in T cells. We also demonstrate that the IRF4 T95R variant is able to bind the canonical GAAA binding site as well as a novel GATA binding site. Therefore, we propose that the IRF4 T95R variant is defined as a neomorphic variant, as it has gained novel DNA-binding functions. This increase in DNA-binding sequence promiscuity may result in a dominant negative redistribution of the wild-type IRF4 and the combined immunodeficiency phenotype in the proband. We have characterized a novel neomorphic variant in the IRF4 gene and defined a novel human IEI which highlights the potential of IRF4 as an immunomodulatory therapeutic target.
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Clinical and laboratory characterization of allergic immune dysregulation caused by a heterozygous gain-of-function mutation in JAK1 (2019)
Monogenic immune disorders are a group of conditions caused by single gene mutations affecting how the immune system develops, functions, or both. It is now appreciated that certain monogenic immune disorders can present with severe allergic disease, such as asthma, food allergy, elevated eosinophil counts and/or atopic dermatitis. Studying single-gene defects that lead to atopy has identified critical molecules in the pathogenesis of allergic inflammation. These discoveries have created new therapeutic targets for allergic diseases, which carry an immense health and economic burden in Canada. Germline gain-of-function mutations in JAK1 are a newly described monogenic cause of severe atopy, with affected patients demonstrating profound eosinophilia and allergic inflammation. The initial report identified a dramatic clinical response to the combined JAK1/2 inhibitor ruxolitinib. We sought to determine the long-term clinical outcomes and response to ruxolitinib of patients carrying a germline JAK1 gain-of-function mutation. We further aimed to characterize the mechanisms behind JAK1-mediated atopic immune dysregulation, including its effect on T lymphocytes–key regulators in allergic inflammation–and hematopoiesis. We demonstrate that long-term ruxolitinib use is associated with improvements in growth, eosinophilia, and allergic inflammation, however, anemia represents a dose-limiting adverse effect. T cell immunophenotypic analysis revealed severe skewing towards a TH2 phenotype pre-ruxolitinib treatment, in keeping with the allergic clinical manifestations. RNA sequencing data from patients and a transgenic zebrafish model both containing the same JAK1 gain-of-function mutation identified increased expression of genes involved in cytokine signaling, type 1 interferon and antiviral immune responses, and alternative macrophage activation, as well as genes whose role in allergic immune dysregulation warrants further investigation. In conclusion, this work demonstrates a critical role for JAK1 in atopic immune dysregulation, specifically driving lymphocyte responses towards a TH2 phenotype. Combined JAK1/2 inhibition can reverse much of the allergic inflammation, with dramatic clinical effects. This has important implications for our understanding of the pathogenesis and potential therapeutic targets for early life allergic immune dysregulation.
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Early-life gut microbiota dysbiosis in children with atopic dermatitis (2019)
Introduction:Atopic dermatitis (AD) is a prevalent, heterogeneous allergic disease of the skin, impacting quality of life and often a prelude to other incurable allergic diseases. Microbes residing in the gut in early-life play an important role in shaping the function of the immune system and may be critical in the prevention or treatment of AD. Characterizing the early-life gut microbiota in children with AD may lead to new therapeutic and preventative measures involving alteration of the gut microbiota.Hypotheses: The specific hypotheses tested in this study are: 1) there is dysbiosis (or imbalance) in the gut microbiota of infants with clinically relevant AD phenotypes; and 2) there are differences in gut microbiota composition between extrinsic and intrinsic AD endotypes.Methods:Leveraging stool samples and data from the Canadian Healthy Infant Longitudinal Development (CHILD) study, early-life gut microbiota of deeply phenotyped children with AD was assessed. AD at five years of age, moderate/severe AD, and persistent AD phenotypes and intrinsic and extrinsic AD endotypes were formalized. 16S rRNA gene sequencing was used to analyze stool samples to assess gut microbial diversity, maturation and taxa abundance between phenotypes and healthy controls.Results:Gut microbial diversity and maturation was significantly decreased in children with AD at five years of age compared to healthy controls. Epulopiscium, Aggregatibacter, Turicibater, Phascolarctobacterium, Citrobacter and Prevotella were detected at significantly different levels in the early-life gut microbiota of infants with clinically-relevant AD and healthy controls. Microbial diversity and gut maturation indices in children with extrinsic AD were significantly decreased compared to healthy controls, whereas children with intrinsic AD had no differences in diversity or gut maturation compared to healthy controls. Taxa abundance were different between intrinsic and extrinsic AD endotypes.Conclusion:There are differences in the early-life gut microbiota of children with various clinically-relevant AD phenotypes compared to children without AD. Thoroughly phenotyping AD is important for proper treatment or prevention, particularly for considering gut microbiota alteration as a therapeutic method. This knowledge contributes to the process of profiling the gut microbiota of children with AD with the goal of creating live biotherapeutics for prevention of AD.
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Establishing the functional role of ORMDL3 in innate immunity (2012)
Asthma and allergic diseases are rapidly becoming the most common chronicdiseases in the developed world. Nearly 1 in 3 Canadians suffer from some form of allergyand more than 300 million individuals in the developed world suffer from asthma. Thesecomplex disorders are caused by the interaction of various genetic and environmental factors.Genome-wide association studies have been widely used to identify genes associated withasthma susceptibility. The gene, ORMDL3, was shown to be associated with early-onsetasthma. Asthmatic patients have elevated expression levels of this gene. The gene encodes atransmembrane protein localized in the endoplasmic reticulum (ER) that may be involved inER stress and inflammation. Its functional role in asthma pathogenesis, however, has yet tobe elucidated. In this research, we investigated the functional role of ORMDL3 in innateimmunity. Experimentally, ORMDL3 expression levels were manipulated in vitro in airwaycells using overexpression plasmid and siRNA technologies. The effects of ORMDL3expression levels on inflammatory responses were then explored. After manipulation ofORMDL3 expression levels, cells were stimulated with various immune response-inducingfactors. Supernatants collected after stimulation were analyzed and no differences in proinflammatorycytokine production were observed. These results suggest that variation inORMDL3 expression levels does not affect innate immune production of IL-6 and IL-8 inairway cells. ORMDL3 knockdown also did not affect expression of other immune-relatedgenes.
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Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease (2010)
IkBα is an important regulator of inflammation. Single nucleotide polymorphisms (SNPs) rs3138053, rs2233406 and rs2233409 in the promoter of the gene NFKBIA, which encodes for IkBα, have been shown to be associated with a variety of infectious and inflammatory conditions. In this study, we investigated the functional impact of the promoter variants of NFKBIA on human immune responsiveness. Using a coding SNP that was in strong linkage disequilibrium (LD) with NFKBIA SNPs rs3138053/rs2233406/rs2233409, we designed and validated an allele-specific PCR assay that could detect subtle differences in allele ratios between the major (ACC) and minor (GTT) promoter variants of SNPs rs3138053/rs2233406/rs2233409. Peripheral blood mononuclear cells (PBMCs) of homozygous (ACC/ACC) and heterozygous (ACC/GTT) individuals were stimulated with 100ng/ml LPS and live cultures of Streptococcus pneumoniae (moi 7.8-30) serotype 14 for 3 and 4 hours. PBMCs of neonatal NFKBIA homozygotes and heterozygotes were stimulated with various Toll-like-receptor (TLR) ligands of the innate immunity cascade to assay for differences in the innate immune response.NFKBIA heterozygotes of European descent displayed 1.21 (1.14-1.27 95% CI)-1.26 (1.18-1.34 95% CI) fold higher expression of the major allele transcript (ACC) relative to the minor allele transcript (GTT). For the same ethnicity, at 3 hours stimulation, NFKBIA homozygotes (ACC/ACC) produced higher levels of NFKBIA mRNA than heterozygotes following stimulation with LPS (1.4 fold. p=0.0095) and S. pneumoniae (1.51 fold, p=0.024). Higher TNFα secretion was seen from PBMCs of heterozygotes as compared to homozygotes (of European descent) in the presence of LPS (1.57 fold , p
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Publications
- A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: Results from ReACCh-Out and the CAPRI registry (2024)
Rheumatology (United Kingdom), 63 (SI2), SI173-SI179 - A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis (2024)
medRxiv, - A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring (2024)
Cellular and Molecular Gastroenterology and Hepatology, 17 (5), 827-852 - Antibiotics taken within the first year of life are linked to infant gut microbiome disruption and elevated atopic dermatitis risk (2024)
Journal of Allergy and Clinical Immunology, 154 (1), 131-142 - Association between Maternal Perinatal Stress and Depression on Infant DNA Methylation in the First Year of Life (2024)
Research Square, - Association of Human Milk Fatty Acid Composition with Maternal Cardiometabolic Diseases: An Exploratory Prospective Cohort Study (2024)
Breastfeeding Medicine, 19 (5), 357-367 - Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy (2024)
Nature Genetics, 56 (4), 585-594 - Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts (2024)
Clinical Epigenetics, 16 (1) - Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (Genome Medicine, (2023), 15, 1, (22), 10.1186/s13073-023-01173-8) (2024)
Genome Medicine, 16 (1) - Development and Validation of an Asthma Policy Model for Canada: Lifetime Exposures and Asthma outcomes Projection (LEAP) (2024)
- Development and Validation of an Asthma Policy Model for Canada:Lifetime Exposures and Asthma outcomes Projection (LEAP) (2024)
medRxiv, - Divergent maturational patterns of the infant bacterial and fungal gut microbiome in the first year of life are associated with inter-kingdom community dynamics and infant nutrition (2024)
Microbiome, 12 (1) - Early Life Predictors of Child Development at Kindergarten: A Structural Equation Model using a Longitudinal Cohort (2024)
- Early prediction of pediatric asthma in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort using machine learning (2024)
Pediatric Research, 95 (7), 1818-1825 - Early-life cytomegalovirus infection is associated with changes in the intestinal microbiota and increased risk of atopy (2024)
- Erratum: Correction to: Examining psychosocial pathways to explain the link between breastfeeding practices and child behaviour in a longitudinal cohort (BMC public health (2024) 24 1 DOI: 10.1186/s12889-024-17994-0) (2024)
BMC public health, 24 (1), 1611 - Examining psychosocial pathways to explain the link between breastfeeding practices and child behaviour in a longitudinal cohort (2024)
BMC Public Health, 24 (1) - Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency (2024)
Pediatric Allergy and Immunology, 35 (2) - Finding the balance: The influence of movement behaviours on childhood behaviour problems (2024)
Mental Health and Physical Activity, 26 - Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism (2024)
Human Genetics and Genomics Advances, 5 (1) - Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy (2024)
eBioMedicine, 101 - Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children (2024)
Journal of Experimental Medicine, 221 (2) - Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond (2024)
Trends in Immunology, 45 (2), 138-153 - Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children (2024)
Nature Communications, 15 (1) - Impact analysis of infant antibiotic exposure on the burden of asthma: a simulation modeling study (2024)
- Inborn errors of immunity in adulthood (2024)
Allergy, Asthma and Clinical Immunology, 20 (1) - Infant use of acid-suppressant medication, C. difficile colonization, and childhood body mass index and asthma in a Canadian cohort (2024)
Research Square, - Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection (2024)
Human Genetics and Genomics Advances, 5 (3) - MAGinator enables accurate profiling of de novo MAGs with strain-level phylogenies (2024)
Nature Communications, 15 (1) - Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry (2024)
- Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity (2024)
Gut Microbes, 16 (1) - Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development (2024)
Cell, 187 (19), 5431-5452 - Multimodal machine learning for modeling infant head circumference, mothers’ milk composition, and their shared environment (2024)
Scientific Reports, 14 (1) - Naturally occurring splice variants dissect the functional domains of BHC80 and emphasize the need for RNA analysis (2024)
American Journal of Medical Genetics, Part A, 194 (6) - Organophosphate ester flame retardants and plasticizers in house dust and mental health outcomes among Canadian mothers: A nested prospective cohort study in CHILD (2024)
Environmental Research, 240 - Persistent DNA Methylation Changes across the First Year of Life and Prenatal NO2 Exposure in a Canadian Prospective Birth Study (2024)
Environmental Health Perspectives, 132 (4) - Persistent DNA Methylation Changes across the First Year of Life and Prenatal NO2 Exposure in a Canadian Prospective Birth Study (2024)
Environmental Health Perspectives, - Pre-labor and post-labor cesarean delivery and early childhood adiposity in the Canadian Healthy Infant Longitudinal Development (CHILD) Cohort Study (2024)
International Journal of Obesity, 48 (5), 717-724 - Sensory neurons promote immune homeostasis in the lung (2024)
Cell, 187 (1), 44-61.e17 - Should “primary immune disorder” replace “inborn error of immunity”? Names matter, but there is room for both (2024)
Journal of Allergy and Clinical Immunology, 153 (6), 1546-1547 - Stress and anxiety during pregnancy and length of gestation: a federated study using data from five Canadian and European birth cohorts (2024)
European Journal of Epidemiology, 39 (7), 773-783 - The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study (2024)
International Breastfeeding Journal, 19 (1) - Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study (2024)
Applied Physiology, Nutrition and Metabolism, 49 (6), 868-873 - Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study (2024)
Applied Physiology, Nutrition, and Metabolism, - A germline heterozygous dominant negativeIKZF2variant causing syndromic primary immune regulatory disorder and ICHAD (2023)
- A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency (2023)
Science Immunology, 8 (79) - A second update on mapping the human genetic architecture of COVID-19 (2023)
Nature, 621 (7977), E7-E26 - Association between gas stove use and childhood asthma in the Canadian CHILD Cohort Study (2023)
Canadian Journal of Public Health, 114 (4), 705-708 - Association of COVID-19 Government-Instituted Mask Mandates with Incidence of Mask Use among Children in Alberta, Canada (2023)
JAMA Network Open, 6 (6) - Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency (2023)
Nature, 623 (7988), 803-813 - Autosomal Recessive Inflammatory Skin Disease Caused by a Novel Biallelic Loss-of-Function Variant in CARD11 (2023)
Journal of Clinical Immunology, - Breastfeeding enrichment of B. longum subsp. infantis mitigates the effect of antibiotics on the microbiota and childhood asthma risk (2023)
Med, 4 (2), 92-112.e5 - Cohort profile: investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort (2023)
Epidemiology and Health, 45, 1-11 - Corrigendum: The human milk proteome and allergy of mother and child: exploring associations with protein abundances and protein network connectivity(Front. Immunol., (2022), 13, (977470), 10.3389/fimmu.2022.977470) (2023)
Frontiers in Immunology, 14 - Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease (2023)
Nature Communications, 14 (1) - Di-(2-Ethylhexyl) Phthalate (DEHP) in House Dust in Canadian Homes: Behaviors and Associations with Housing Characteristics and Consumer Products (2023)
Indoor Air, 2023 - DNA methylation is not associated with sensitization to or dietary introduction of highly allergenic foods in a subset of the CHILD cohort at age 1 year (2023)
Journal of Allergy and Clinical Immunology: Global, 2 (4) - Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay (2023)
Journal of Medical Genetics, 60 (11), 1092-1104 - Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis (2023)
OpenAlex, - Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis (2023)
BMC Medicine, 21 (1) - Erratum: Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253, 810 singletons in 16 birth cohort studies (PLoS Med (2023) 20:1 (e1004036) DOI: 10.1371/journal.pmed.1004036) (2023)
PLoS Medicine, 20 (4 Apr) - Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism (2023)
medRxiv, - Generation of a human induced pluripotent stem cell line from a patient with hypomyelinating leukodystrophy 22 (HLD22) (2023)
Stem Cell Research, 71 - Generation of tandem alternative splice acceptor sites and CLTC haploinsufficiency: A cause of CLTC-related disorder (2023)
American Journal of Medical Genetics, Part A, 191 (8), 2219-2224 - Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies (2023)
PLoS Medicine, 20 (1) - Homozygous RMRP Promoter Duplications Cause Severely Reduced Transcript Abundance and SCID Associated with Cartilage Hair Hypoplasia (2023)
Journal of Clinical Immunology, 43 (6), 1139-1142 - Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV–Associated Hodgkin Lymphoma (2023)
medRxiv, - Human germline heterozygous gain-of-functionSTAT6variants cause severe allergic disease (2023)
OpenAlex, - Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia (2023)
Journal of Experimental Medicine, 220 (5) - Impact of Cesarean Delivery and Breastfeeding on Secretory Immunoglobulin A in the Infant Gut Is Mediated by Gut Microbiota and Metabolites (2023)
Metabolites, 13 (2) - Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity (2023)
Journal of Allergy and Clinical Immunology, 151 (4), 818-831 - Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children (2023)
Science, 379 (6632) - Infant Vitamin D Supplements, Fecal Microbiota and Their Metabolites at 3 Months of Age in the CHILD Study Cohort (2023)
Biomolecules, 13 (2) - Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children (2023)
Journal of Allergy and Clinical Immunology, 151 (4), 832-840 - Investigating the effect of early life antibiotic use on asthma and allergy risk in over 600 000 Canadian children: A protocol for a retrospective cohort study in British Columbia and Manitoba (2023)
BMJ Open, 13 (4) - Lack of association between HLA and asymptomatic SARS-CoV-2 infection (2023)
medRxiv, - MAGinator enables strain-level quantification ofde novoMAGs (2023)
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Cell Reports Medicine, 4 (2) - Natural Green Spaces, Sensitization to Allergens, and the Role of Gut Microbiota during Infancy (2023)
mSystems, 8 (2) - Persistent DNA methylation changes associated with prenatal NO2exposure in a Canadian prospective birth study (2023)
- Predictors of SARS-CoV-2 anti-Spike IgG antibody levels following two COVID-19 vaccine doses among children and adults in the Canadian CHILD Cohort (2023)
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Frontiers in Genetics, 14 - Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (2023)
Genome Medicine, 15 (1) - The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes (2023)
Allergy: European Journal of Allergy and Clinical Immunology, 78 (2), 418-428 - The Relationship Between Diet, Gut Microbiota, and Serum Metabolome of South Asian Infants at 1 Year (2023)
Journal of Nutrition, 153 (2), 470-482 - Transcription factor defects in inborn errors of immunity with atopy (2023)
Frontiers in Allergy, 4 - Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs (2023)
Science Immunology, 8 (90) - Validation of the parent global assessment as a health-related quality of life measure in juvenile idiopathic arthritis: results from ReACCh-Out (2023)
Rheumatology (United Kingdom), 62 (SI2), SI152-SI162 - 16-year trends in asthma hospital admissions in Canada (2022)
Annals of Allergy, Asthma and Immunology, 129 (4), 475-480.e2 - A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection (2022)
Nature Immunology, 23 (2), 159-164 - Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning (2022)
Journal of Exposure Science and Environmental Epidemiology, 32 (1), 112-123 - Atopy as Immune Dysregulation: Offender Genes and Targets (2022)
Journal of Allergy and Clinical Immunology: In Practice, 10 (7), 1737-1756 - Author Correction: A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection (Nature Immunology, (2022), 23, 2, (159-164), 10.1038/s41590-021-01030-z) (2022)
Nature Immunology, 23 (2), 341 - Can leaky splicing and evasion of premature termination codon surveillance contribute to the phenotypic variability in Alkuraya-Kucinskas syndrome? (2022)
European Journal of Medical Genetics, 65 (3), 104427 - Can tandem alternative splicing and evasion of premature termination codon surveillance contribute to attenuated Peutz–Jeghers syndrome? (2022)
American Journal of Medical Genetics, Part A, 188 (10), 3089-3095 - Childhood body mass index and associations with infant gut metabolites and secretory IgA: findings from a prospective cohort study (2022)
International Journal of Obesity, 46 (9), 1712-1719 - Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis (2022)
Journal of Clinical Immunology, 42 (7), 1354-1359 - Development of a predictive algorithm to identify pre-school children at risk for behavior changes associated with sleep-related breathing disorders (2022)
Sleep Medicine, 100, 472-478 - Development of a Symptom-Based Tool for Screening of Children at High Risk of Preschool Asthma (2022)
JAMA Network Open, 5 (10), E2234714 - Dibutyl phthalate exposure alters T-cell subsets in blood from allergen-sensitized volunteers (2022)
Indoor Air, 32 (4) - DNA methylation changes in cord blood and the developmental origins of health and disease – a systematic review and replication study (2022)
BMC Genomics, 23 (1) - Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants (2022)
Antibiotics, 11 (7) - Early‐life cytomegalovirus infection is associated with gut microbiota perturbations and increased risk of atopy (2022)
Pediatric Allergy and Immunology, 33 (1) - Factors associated with breast-feeding initiation and continuation in Canadian-born and non-Canadian-born women: a multi-centre study (2022)
Public Health Nutrition, 25 (10), 2822-2833 - From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants (2022)
Children, 9 (10) - Gestational age at birth and body size from infancy through adolescence: findings from analyses of individual data on 253,810 singletons in 16 birth cohort studies (2022)
medRxiv, - HostSeq: A Canadian Whole Genome Sequencing and Clinical Data Resource (2022)
medRxiv, - Human complete NFAT1 deficiency causes a triad of joint contractures, osteochondromas, and B-cell malignancy (2022)
Blood, 140 (17), 1858-1874 - Human genetic and immunological determinants of critical COVID-19 pneumonia (2022)
Nature, - Human germline biallelic complete NFAT1 deficiency causes the triad of progressive joint contractures, osteochondromas, and susceptibility to B cell malignancy (2022)
medRxiv, - Human Germline Heterozygous Gain-of-Function STAT6 Variants Cause Severe Allergic Disease (2022)
medRxiv, - Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation (2022)
JCI Insight, 7 (24) - Inborn Errors of Immunity Associated With Type 2 Inflammation in the USIDNET Registry (2022)
Frontiers in immunology, 13, 831279 - Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates (2022)
Computational and Structural Biotechnology Journal, 20, 4717-4732 - Investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort: study methodology and cohort profile (2022)
medRxiv, - Longitudinal Associations Between Sleep Habits, Screen Time and Overweight, Obesity in Preschool Children (2022)
Nature and Science of Sleep, 14, 1237-1247 - Longitudinal body mass index trajectories at preschool age: children with rapid growth have differential composition of the gut microbiota in the first year of life (2022)
International Journal of Obesity, - Lung clearance index predicts persistence of preschool wheeze (2022)
Pediatric Allergy and Immunology, 33 (1) - Moderate-to-severe lower respiratory tract infection in early life is associated with increased risk of polysensitization and atopic dermatitis: Findings from the CHILD Study (2022)
Journal of Allergy and Clinical Immunology: Global, 1 (2), 73-79 - Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury (2022)
Advanced Science, 9 (3) - Prediction of odds for emergency cesarean section: A secondary analysis of the CHILD term birth cohort study (2022)
PLoS ONE, 17 (10 Oc) - Secretory IgA: Linking microbes, maternal health, and infant health through human milk (2022)
Cell Host and Microbe, 30 (5), 650-659 - Sensory Neurons Promote Immune Homeostasis in the Lung (2022)
SSRN, - Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment (2022)
Frontiers in Pediatrics, 10 - Studying severe long COVID to understand post-infectious disorders beyond COVID-19 (2022)
Nature Medicine, 28 (5), 879-882 - The human milk proteome and allergy of mother and child: Exploring associations with protein abundances and protein network connectivity (2022)
Frontiers in Immunology, 13 - Wheeze trajectories: Determinants and outcomes in the CHILD Cohort Study (2022)
Journal of Allergy and Clinical Immunology, - A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation (2021)
Frontiers in Immunology, 12 - A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization (2021)
Cell Reports Medicine, 2 (5) - Age trends in direct medical costs of pediatric asthma: A population study (2021)
Pediatric Allergy and Immunology, 32 (6), 1374-1377 - Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths (2021)
Science Immunology, 6 (62) - Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life (2021)
eLife, 10 - Bacteroides-dominant gut microbiome of late infancy is associated with enhanced neurodevelopment (2021)
Gut Microbes, - Breastfeeding in the First Days of Life Is Associated With Lower Blood Pressure at 3 Years of Age (2021)
Journal of the American Heart Association, 10 (15) - Causal pathways to health-related quality of life in children with juvenile idiopathic arthritis: Results from the ReACCh-Out cohort (2021)
Rheumatology (United Kingdom), 60 (10), 4691-4702 - Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis (2021)
Pediatric rheumatology online journal, 19 (1), 97 - Composition and associations of the infant gut fungal microbiota with environmental factors and childhood allergic outcomes (2021)
mBio, 12 (3) - Development and Validation of SDBeasy Score as a Predictor of Behavioral Outcomes in Childhood (2021)
American Journal of Respiratory and Critical Care Medicine, 203 (6), 718-725 - Diverse clinical features and diagnostic delay in monogenic inborn errors of immunity: A call for access to genetic testing (2021)
Pediatric Allergy and Immunology, - Early life exposure to phthalates and the development of childhood asthma among Canadian children (2021)
Environmental Research, 197 - Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma (2021)
Environmental Science and Technology Letters, 8 (7), 531-537 - Establishing a link between antibiotics and asthma in early life (2021)
British Columbia Medical Journal, 63 (2), 80-82 - Ethnicity Associations With Food Sensitization Are Mediated by Gut Microbiota Development in the First Year of Life (2021)
Gastroenterology, 161 (1), 94-106 - Exome sequencing enables diagnosis of X-linked hypohidrotic ectodermal dysplasia in patient with eosinophilic esophagitis and severe atopy (2021)
Allergy, Asthma and Clinical Immunology, 17 (1) - From Birth to Overweight and Atopic Disease: Multiple and Common Pathways of the Infant Gut Microbiome (2021)
Gastroenterology, 160 (1), 128-144.e10 - Gut health' and the microbiome in the popular press: A content analysis (2021)
BMJ Open, 11 (7) - Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β (2021)
Journal of Clinical Immunology, 41 (7), 1425-1442 - Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth (2021)
Nutrition Research, 92, 139-149 - Human MALT1 deficiency and predisposition to infections (2021)
Current Opinion in Immunology, 72, 1-12 - Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report (2021)
BMC Pediatrics, 21 (1) - Impact of maternal intrapartum antibiotics, and caesarean section with and without labour on bifidobacterium and other infant gut microbiota (2021)
Microorganisms, 9 (9) - Inborn errors of immunity manifesting as atopic disorders (2021)
Journal of Allergy and Clinical Immunology, - Influence of Neighborhood Characteristics and Weather on Movement Behaviors at Age 3 and 5 Years in a Longitudinal Birth Cohort (2021)
Journal of Physical Activity and Health, 18 (5), 571-579 - MALT1-Dependent Cleavage of HOIL1 Modulates Canonical NF-κB Signaling and Inflammatory Responsiveness (2021)
Frontiers in Immunology, 12 - Maternal consumption of artificially sweetened beverages during pregnancy is associated with infant gut microbiota and metabolic modifications and increased infant body mass index (2021)
Gut Microbes, - Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency (2021)
Journal of Allergy and Clinical Immunology, - Newly developed multiple-breath washout reference equations from the CHILD Cohort Study: implications of poorly fitting equations (2021)
ERJ Open Research, 7 (1), 00301--2020 - Polygenic risk score for atopic dermatitis in the Canadian population (2021)
Journal of Allergy and Clinical Immunology, 147 (1), 406-409 - Prenatal egg consumption and infant sensitization and allergy to egg, peanut, and cow's milk in the CHILD Cohort (2021)
Journal of Allergy and Clinical Immunology: In Practice, 9 (5), 2109-2112.e2 - Reduced peanut sensitization with maternal peanut consumption and early peanut introduction while breastfeeding (2021)
Journal of Developmental Origins of Health and Disease, 12 (5), 811-818 - Soluble low-density lipoprotein receptor-related protein 1 in juvenile idiopathic arthritis (2021)
Journal of Rheumatology, 48 (5), 760-766 - World Health Organization growth standards: How do Canadian children measure up? (2021)
Paediatrics & Child Health, - X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 (2021)
Science Immunology, 6 (62) - A Germline Mutation in the C2 Domain of PLCγ2 Associated with Gain-of-Function Expands the Phenotype for PLCG2-Related Diseases (2020)
Journal of Clinical Immunology, 40 (2), 267-276 - A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection (2020)
Cell, 181 (6), 1194-1199 - A Symptom-Based Algorithm for Screening Preschool Children at Risk of Persistent Asthma Symptoms: The CHILD Cohort Study (2020)
SSRN, - Association of use of cleaning products with respiratory health in a Canadian birth cohort (2020)
CMAJ, 192 (7), E154-E161 - Associations of clinical and inflammatory biomarker clusters with juvenile idiopathic arthritis categories (2020)
Rheumatology (United Kingdom), 59 (5), 1066-1075 - Autoantibodies against type I IFNs in patients with life-threatening COVID-19 (2020)
Science, 370 (6515) - Breastmilk Feeding Practices Are Associated with the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: the CHILD Cohort Study (2020)
Cell Host and Microbe, 28 (2), 285-297.e4 - Can we prevent allergic disease? Understanding the links between the early life microbiome and allergic diseases of childhood (2020)
Current opinion in pediatrics, 32 (6), 790-797 - Cardiorespiratory Monitoring Data during Sleep in Healthy Canadian Infants (2020)
Annals of the American Thoracic Society, 17 (10), 1238-1246 - Clinical and associated inflammatory biomarker features predictive of short-term outcomes in non-systemic juvenile idiopathic arthritis (2020)
Rheumatology (United Kingdom), 59 (9), 2402-2411 - Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs∗15) variant (2020)
Cold Spring Harbor Molecular Case Studies, 6 (3) - Consumption of artificially sweetened beverages during pregnancy impacts infant gut microbiota and body mass index (2020)
bioRxiv, - Cord blood hemopoietic cell receptor expression is associated with early life atopic risk and lung function (2020)
Allergy, 75 (7), 1762--1765 - Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies (2020)
The Lancet Respiratory Medicine, - Development of a Conceptual Model of Childhood Asthma to Inform Asthma Prevention Policies (2020)
- Dibutyl Phthalate Augments Allergen-induced Lung Function Decline and Alters Human Airway Immunology A Randomized Crossover Study (2020)
American Journal of Respiratory and Critical Care Medicine, 202 (5), 672-680 - Ethnic differences in maternal diet in pregnancy and infant eczema (2020)
PLoS ONE, 15 (5) - Human milk fungi: environmental determinants and inter-kingdom associations with milk bacteria in the CHILD Cohort Study (2020)
BMC Microbiology, 20 (1) - Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1 (2020)
PLOS ONE, - Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 (2020)
Science, 370 (6515) - Increased Mask Use and Fewer Gatherings Associated with Lower SARS-CoV-2 Seropositivity among Young School-Age Children (2020)
SSRN, - Maternal diet and the serum metabolome in pregnancy: Robust dietary biomarkers generalizable to a multiethnic birth cohort (2020)
Current Developments in Nutrition, 4 (10) - Maternal psychological distress before birth influences gut immunity in mid-infancy (2020)
Clinical and Experimental Allergy, 50 (2), 178-188 - Mining the infant gut microbiota for therapeutic targets against atopic disease (2020)
Allergy: European Journal of Allergy and Clinical Immunology, 75 (8) - Natural environments in the urban context and gut microbiota in infants (2020)
Environment International, 142 - Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells (2020)
International Journal of Obesity, - Recurrent sterile abscesses in a case of X-linked neutropenia (2020)
Pediatric Dermatology, 37 (4), 742-744 - Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis (2020)
Frontiers in Immunology, 11 - Sex-specific association of human milk hormones and asthma in the CHILD cohort (2020)
Pediatric Allergy and Immunology, 31 (5), 570-573 - STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells (2020)
EMBO Molecular Medicine, 12 (8) - The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms (2020)
American Journal of Human Genetics, 106 (2), 143-152 - The relationship between machine-learning-derived sleep parameters and behavior problems in 3- And 5-year-old children: Results from the CHILD Cohort study (2020)
Sleep, 43 (12) - Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization: implications for viral respiratory infections (2020)
Gut microbes, 12 (1), 1799734 - Worse Quality of Life, Function, and Pain in Children With Enthesitis, Irrespective of Their Juvenile Arthritis Category (2020)
Arthritis Care and Research, 72 (3), 441-446 - An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. (2019)
Nature chemical biology, - An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source. (2019)
BMC infectious diseases, - Associations between concentrations of perfluoroalkyl substances in human plasma and maternal, infant, and home characteristics in Winnipeg, Canada. (2019)
Environmental pollution (Barking, Essex : 1987), - Associations between meeting the Canadian 24-Hour Movement Guidelines for the Early Years and behavioral and emotional problems among 3-year-olds. (2019)
Journal of science and medicine in sport, - Clostridioides difficile Colonization Is Differentially Associated With Gut Microbiome Profiles by Infant Feeding Modality at 3–4 Months of Age (2019)
Frontiers in Immunology, 10 - Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variants. (2019)
Pediatric rheumatology online journal, - Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors. (2019)
Cell host & microbe, - Early life exposure to phthalates in the Canadian Healthy Infant Longitudinal Development (CHILD) study: a multi-city birth cohort. (2019)
Journal of exposure science & environmental epidemiology, - Germline CBM-opathies: From immunodeficiency to atopy. (2019)
The Journal of allergy and clinical immunology, - Human Milk Fatty Acid Composition Is Associated with Dietary, Genetic, Sociodemographic and Environmental Factors in the CHILD Cohort (P08-114-19). (2019)
Current Developments in Nutrition, - Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study. (2019)
The American journal of clinical nutrition, - Integrated Analysis of Human Milk Microbiota With Oligosaccharides and Fatty Acids in the CHILD Cohort. (2019)
Frontiers in nutrition, - Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age. (2019)
Maternal and child health journal, - Measles Maternal Antibodies With Low Avidity Do Not Interfere With the Establishment of Robust Quantity and Quality Antibody Responses After the Primary Dose of Measles, Mumps, and Rubella Vaccine Administered at 12-Months of Age. (2019)
Journal of the Pediatric Infectious Diseases Society, - Non-nutritive sweetener consumption during pregnancy affects adiposity in mouse and human offspring (2019)
- Novel Exonic Deletions in TTC7A in a Newborn with Multiple Intestinal Atresia and Combined Immunodeficiency. (2019)
Journal of clinical immunology, - Patterns of health care use related to respiratory conditions in early life: A birth cohort study with linked administrative data. (2019)
Pediatric pulmonology, - Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort. (2019)
The Journal of rheumatology, - Prenatal depression and birth mode sequentially mediate maternal education's influence on infant sleep duration. (2019)
Sleep medicine, - Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization. (2019)
The Journal of allergy and clinical immunology, - Real-World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results from a Canadian Cohort. (2019)
Arthritis care & research, - Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization. (2019)
The Journal of allergy and clinical immunology, - Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study. (2019)
PloS one, - Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2 (2019)
- The impact of habitat quality inside protected areas on distribution of the Dominican Republic's last endemic non-volant land mammals. (2019)
Journal of mammalogy, - Thinking bigger: How early‐life environmental exposures shape the gut microbiome and influence the development of asthma and allergic disease (2019)
Allergy, - Timing of Introduction, Sensitization and Allergy to Highly-Allergenic Foods at Age 3 Years in a General-Population Canadian Cohort. (2019)
The journal of allergy and clinical immunology. In practice, - TLR9 limits enteric antimicrobial responses and promotes microbiota-based colonisation resistance during Citrobacter rodentium infection. (2019)
Cellular microbiology, - Trajectories of Depressive Symptoms and Perceived Stress From Pregnancy to the Postnatal Period Among Canadian Women: Impact of Employment and Immigration. (2019)
American journal of public health, - A107 TOLL LIKE RECEPTOR 9 LIMITS INTESTINAL INFLAMMATION AND PROMOTES MICROBIOTA BASED COLONIZATION RESISTANCE DURING CITROBACTER RODENTIUM INFECTION. (2018)
Journal of the Canadian Association of Gastroenterology, - Ancient DNA of the extinct Jamaican monkey Xenothrix reveals extreme insular change within a morphologically conservative radiation. (2018)
Proceedings of the National Academy of Sciences of the United States of America, - Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life. (2018)
JAMA pediatrics, - Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production. (2018)
Cell death & disease, - Determining threatened species distributions in the face of limited data: Spatial conservation prioritization for the Chinese giant salamander (Andrias davidianus). (2018)
Ecology and Evolution, - Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria-based assessment. (2018)
Paediatric and perinatal epidemiology, - Differential loss of components of traditional ecological knowledge following a primate extinction event. (2018)
Royal Society open science, - Early Holocene human presence in Madagascar evidenced by exploitation of avian megafauna. (2018)
Science advances, - Exclusive breastfeeding in hospital predicts longer breastfeeding duration in Canada: Implications for health equity. (2018)
Birth (Berkeley, Calif.), - Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and Feeding Practices. (2018)
The Journal of nutrition, - Human milk oligosaccharide profiles and food sensitization among infants in the CHILD Study. (2018)
Allergy, - IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis. (2018)
Arthritis & rheumatology (Hoboken, N.J.), - Imminent extinction in the wild of the world's largest amphibian. (2018)
Current biology : CB, - Impact of maternal pre‐pregnancy overweight on infant overweight at 1 year of age: associations and sex‐specific differences (2018)
Pediatric Obesity, - Infant Feeding and Weight Gain: Separating Breast Milk From Breastfeeding and Formula From Food. (2018)
Pediatrics, - IVIg and LPS Co-stimulation Induces IL-10 Production by Human Monocytes, Which Is Compromised by an FcγRIIA Disease-Associated Gene Variant. (2018)
Frontiers in immunology, - New genus of extinct Holocene gibbon associated with humans in Imperial China. (2018)
Science (New York, N.Y.), - Peptide-Gold Nanoparticle Hybrids as Promising Anti-Inflammatory Nanotherapeutics for Acute Lung Injury: In Vivo Efficacy, Biodistribution, and Clearance. (2018)
Advanced healthcare materials, - Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms. (2018)
Sleep medicine, - Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children. (2018)
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, - Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants. (2018)
Pediatric pulmonology, - Residential green space and pathways to term birth weight in the Canadian Healthy Infant Longitudinal Development (CHILD) Study. (2018)
International journal of health geographics, - Risk for Maternal Depressive Symptoms and Perceived Stress by Ethnicities in Canada: From Pregnancy Through the Preschool Years. (2018)
Canadian journal of psychiatry. Revue canadienne de psychiatrie, - Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring. (2018)
JAMA pediatrics, - Shorter sleep duration is associated with reduced cognitive development at two years of age. (2018)
Sleep medicine, - Size-dependent anti-inflammatory activity of a peptide-gold nanoparticle hybrid in vitro and in a mouse model of acute lung injury. (2018)
Acta biomaterialia, - The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex. (2018)
Frontiers in immunology, - The Chinese giant salamander exemplifies the hidden extinction of cryptic species. (2018)
Current biology : CB, - The importance of functional validation after next‐generation sequencing: evaluation of a novel CARD11 variant (2018)
Pediatric Allergy and Immunology, - Unexpected diversity within the extinct elephant birds (Aves: Aepyornithidae) and a new identity for the world's largest bird. (2018)
Royal Society open science, - Ventilation inhomogeneity in infants with recurrent wheezing. (2018)
Thorax, - What do participants in a birth cohort study know about their homes? (2018)
15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018, - A new species of extinct Late Quaternary giant tortoise from Hispaniola. (2017)
Zootaxa, - Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life. (2017)
International journal of obesity (2005), - Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting. (2017)
The Journal of allergy and clinical immunology, - Asthma and the microbiome: defining the critical window in early life (2017)
Allergy, Asthma & Clinical Immunology, 13 (1) - Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study. (2017)
The European respiratory journal, - Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016. (2017)
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, - Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy. (2017)
Frontiers in pediatrics, - Chronic Mucocutaneous Candidiasis, ACT1 Deficiency (2017)
Encyclopedia of Medical Immunology, , 1--4 - Complex Admixture Preceded and Followed the Extinction of Wisent in the Wild. (2017)
Molecular biology and evolution, - Description of a new species of Hoolock gibbon (Primates: Hylobatidae) based on integrative taxonomy. (2017)
American journal of primatology, - Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance. (2017)
BMJ open, - Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation. (2017)
The Journal of infectious diseases, - Epidemiology and Outcomes in Critically Ill Patients with Human Immunodeficiency Virus Infection in the Era of Combination Antiretroviral Therapy. (2017)
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, - Ethnic and diet-related differences in the healthy infant microbiome. (2017)
Genome medicine, - EVER1 and EVER2 Mutations in Epidermodysplasia Verruciformis (2017)
Encyclopedia of Medical Immunology, , 1--6 - Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios. (2017)
Microbiome, - Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4 Months: Differences in Relative versus Absolute Concentrations. (2017)
Frontiers in nutrition, - Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort. (2017)
Pediatric rheumatology online journal, - Imperial trophy or island relict? A new extinction paradigm for Père David's deer: a Chinese conservation icon. (2017)
Royal Society open science, - In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory? (2017)
PLoS ONE, - JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome. (2017)
The Journal of allergy and clinical immunology, - Long-term archives reveal shifting extinction selectivity in China's postglacial mammal fauna. (2017)
Proceedings. Biological sciences, - Maternal depressive symptoms linked to reduced fecal Immunoglobulin A concentrations in infants. (2017)
Brain, behavior, and immunity, - Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study. (2017)
The Journal of pediatrics, - Monogenic immune disorders and severe atopic disease (2017)
Nature Genetics, 49 (8), 1162--1163 - Mycobacterium branderi infection: Case report and literature review of an unusual and difficult-to-treat non-tuberculous mycobacterium. (2017)
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, - Newborn screening for severe combined immunodeficiency: a primer for clinicians. (2017)
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, - Parent-reported symptoms of sleep disordered breathing is associated with increased behavioral problems at 2 years of age: The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. (2017)
Sleep, - Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: effects on allergic diseases. (2017)
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, - Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells. (2017)
Genes and immunity, - Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study. (2017)
The Journal of allergy and clinical immunology, - Quaternary vertebrate faunas from Sumba, Indonesia: implications for Wallacean biogeography and evolution. (2017)
Proceedings. Biological sciences, - Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen. (2017)
PloS one, - Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling (2017)
Journal of Visualized Experiments, (125) - Sex-specific impact of asthma during pregnancy on infant gut microbiota. (2017)
The European respiratory journal, - Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming. (2017)
Immunity, - The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus. (2017)
Clinical immunology (Orlando, Fla.), - Timing of food introduction and development of food sensitization in a prospective birth cohort. (2017)
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, - Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort. (2017)
Pain, - treeman: an R package for efficient and intuitive manipulation of phylogenetic trees. (2017)
BMC research notes, - What Determines Do-Not-Resuscitate Status in Critically Ill HIV Patients? (2017)
Open forum infectious diseases, - A comparative approach to assess drivers of success in mammalian conservation recovery programs. (2016)
Conservation biology : the journal of the Society for Conservation Biology, - A Family History of Psoriasis in a First-degree Relative in Children with JIA: to Include or Exclude? (2016)
- A humanized microbiota mouse model of ovalbumin-induced lung inflammation (2016)
Gut Microbes, 7 (4), 1-11 - A humanized microbiota mouse model of ovalbumin-induced lung inflammation. (2016)
Gut microbes, 7 (4), 342-352 - Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease. (2016)
- AllerGen’s 8th research conference. (2016)
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, - Assessing current genetic status of the Hainan gibbon using historical and demographic baselines: implications for conservation management of species of extreme rarity. (2016)
Molecular ecology, - Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index. (2016)
JAMA pediatrics, - Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model. (2016)
EBioMedicine, - Cystic Fibrosis: Modifier Genes (2016)
eLS, - Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells (2016)
Biomaterials, 111, 90-102 - Evolutionary History of the Nesophontidae, the Last Unplaced Recent Mammal Family. (2016)
Molecular biology and evolution, - Exome Sequencing and the Management of Neurometabolic Disorders. (2016)
The New England journal of medicine, - Gene expression deconvolution for uncovering molecular signatures in response to therapy in juvenile idiopathic arthritis (2016)
PLoS ONE, 11 (5) - Harmonization of Food-Frequency Questionnaires and Dietary Pattern Analysis in 4 Ethnically Diverse Birth Cohorts. (2016)
The Journal of nutrition, - High fecal IgA is associated with reduced Clostridium difficile colonization in infants. (2016)
Microbes and infection, - Holocene range collapse of giant muntjacs and pseudoâendemism in the Annamite large mammal fauna (2016)
Journal of biogeography., - How many remnant gibbon populations are left on Hainan? Testing the use of local ecological knowledge to detect cryptic threatened primates. (2016)
American journal of primatology, - Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study. (2016)
BJOG : an international journal of obstetrics and gynaecology, - Infant gut immunity: a preliminary study of IgA associations with breastfeeding. (2016)
- IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae. (2016)
- Millennial-scale faunal record reveals differential resilience of European large mammals to human impacts across the Holocene. (2016)
Proceedings. Biological sciences, - Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab. (2016)
- Presence of Archaea in the Indoor Environment and Their Relationships with Housing Characteristics. (2016)
Microbial ecology, - Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015. (2016)
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, - Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma. (2016)
Clinical science (London, England : 1979), - Spatiotemporal requirements of the Hainan gibbon: Does home range constrain recovery of the world's rarest ape? (2016)
American journal of primatology, - Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function. (2016)
Journal of Clinical Investigation, - Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation. (2016)
Clinical immunology (Orlando, Fla.), - The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort. (2016)
- A new subspecies of hutia (Plagiodontia, Capromyidae, Rodentia) from southern Hispaniola. (2015)
Zootaxa, - Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids. (2015)
- Ancient proteins resolve the evolutionary history of Darwin's South American ungulates. (2015)
Nature, - Climate impacts on transocean dispersal and habitat in gray whales from the Pleistocene to 2100. (2015)
Molecular ecology, - Early infancy microbial and metabolic alterations affect risk of childhood asthma. (2015)
Science translational medicine, - Historical data as a baseline for conservation: reconstructing long-term faunal extinction dynamics in Late Imperial-modern China. (2015)
Proceedings. Biological sciences, - HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. (2015)
- Identifying environmental versus phylogenetic correlates of behavioural ecology in gibbons: implications for conservation management of the world's rarest ape. (2015)
BMC evolutionary biology, - Impaired NLRP3 inflammasome activity during fetal development regulates IL-1β production in human monocytes. (2015)
- Infant gut microbiota and food sensitization: associations in the first year of life. (2015)
- Interview-based sighting histories can inform regional conservation prioritization for highly threatened cryptic species. (2015)
The Journal of applied ecology, - Perinatal Exposure to Traffic-Related Air Pollution and Atopy at 1 Year of Age in a Multi-Center Canadian Birth Cohort Study. (2015)
- Spatial autocorrelation and congruence in the distribution of language and mammal richness: a reply to Cardillo et al. (2015). (2015)
Proceedings. Biological sciences, - The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures. (2015)
- The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. (2015)
- The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking. (2015)
- The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects. (2015)
- The hygiene hypothesis: current perspectives and future therapies. (2015)
- The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort. (2015)
- The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. (2015)
- The price of conserving avian phylogenetic diversity: a global prioritization approach. (2015)
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, - The Serine Protease Autotransporter Pic Modulates Citrobacter rodentium Pathogenesis and Its Innate Recognition by the Host. (2015)
- Unexpected evolutionary diversity in a recently extinct Caribbean mammal radiation. (2015)
Proceedings. Biological sciences, - A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection. (2014)
- An antibiotic-altered microbiota provides fuel for the enteric foe. (2014)
- Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: a candidate gene case-control study. (2014)
- Associations between bacterial communities of house dust and infant gut. (2014)
Environmental research, - Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. (2014)
- Combined immunodeficiency associated with homozygous MALT1 mutations. (2014)
- Comparison of questionnaire responses with biomarkers of tobacco smoke exposure in a Canadian birth cohort at three months of age. (2014)
- Current concepts: host-pathogen interactions in cystic fibrosis airways disease. (2014)
- Dual proteolytic pathways govern glycolysis and immune competence. (2014)
- Hierarchical maturation of innate immune defences in very preterm neonates. (2014)
- Is local ecological knowledge a useful conservation tool for small mammals in a Caribbean multicultural landscape? (2014)
Biological conservation., - Late Holocene range collapse in a former British seabird species (2014)
Journal of biogeography., - Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency. (2014)
- Optimizing pediatric venipuncture: ensuring successful blood sample collection with minimal stress and pain. (2014)
- Optimizing subject retention in a longitudinal birth cohort study: lessons learned from the Vancouver site of the CHILD Study. (2014)
- Spatial congruence in language and species richness but not threat in the world's top linguistic hotspot. (2014)
Proceedings. Biological sciences, - The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency. (2014)
- The early life gut microbiota and atopic disease. (2014)
- The impact of the intestinal microbiome on human immune development and atopic disease. (2014)
- To see or not to see: investigating detectability of Ganges River dolphins using a combined visual-acoustic survey. (2014)
PloS one, - Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis. (2014)
ACS Chemical Biology, 9 (1), 247-257 - Unbiased screening of marine sponge extracts for antiinflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis (2014)
ACS Chemical Biology, 9 (1), 247-257 - A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust. (2013)
- Amino acid structure determines the immune responses generated by peptide-gold nanoparticle hybrids (2013)
Particle and Particle Systems Characterization, 30 (12), 1039-1043 - Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates. (2013)
- Can local ecological knowledge be used to assess status and extinction drivers in a threatened freshwater cetacean? (2013)
Biological conservation., - Canine evolution in sabretoothed carnivores: natural selection or sexual selection? (2013)
PloS one, - Could brown bears (Ursus arctos) have survived in Ireland during the Last Glacial Maximum? (2013)
Biology letters, - Functional analysis of the impact of ORMDL3 expression on inflammation and activation of the unfolded protein response in human airway epithelial cells. (2013)
- Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia. (2013)
- Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. (2013)
- Human primary immunodeficiencies causing defects in innate immunity. (2013)
- IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates. (2013)
- Innate Immunity (2013)
Primary Immunodeficiency Diseases, , 117--130 - Neonatal pain-related stress and NFKBIA genotype are associated with altered cortisol levels in preterm boys at school age. (2013)
- Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective. (2013)
- Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells. (2013)
- Severe combined immunodeficiency (SCID) in Canadian children: a national surveillance study. (2013)
- The evolution of sexual dimorphism in New Zealand giant moa (Dinornis) and other ratites. (2013)
Proceedings. Biological sciences, - Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe). (2012)
- Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses. (2012)
- Do adult disease severity subclassifications predict use of cyclophosphamide in children with ANCA-associated vasculitis? An analysis of ARChiVe study treatment decisions. (2012)
- Increased sensitivity of the European medicines agency algorithm for classification of childhood granulomatosis with polyangiitis. (2012)
The Journal of rheumatology, - Inflammasome-mediated IL-1β production in humans with cystic fibrosis. (2012)
- Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants. (2012)
- Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication. (2012)
- Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant. (2012)
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, - Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant. (2012)
Journal of Otolaryngology - Head and Neck Surgery, 41 (1) - Successful approach to treatment of Helicobacter bilis infection in X-linked agammaglobulinemia. (2012)
- Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. (2011)
- Potential sources of phthalate exposure in a Vancouver birth cohort at three months of age (2011)
12th International Conference on Indoor Air Quality and Climate 2011, 4, 2715-2716 - Potential sources of phthalate exposure in a Vancouver birth cohort at three months of age (2011)
12th International Conference on Indoor Air Quality and Climate 2011, 4, 2715-2716 - The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells. (2011)
- Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation. (2011)
- Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis. (2010)
- Chlamydia pneumoniae infection in preeclampsia. (2010)
- Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort. (2010)
- Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease. (2010)
- Innate immunity. (2010)
- Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome. (2010)
- Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells. (2010)
- Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity. (2010)
- Serious musculoskeletal infections in children receiving anti-tumor necrosis factor-alpha therapy: a case series. (2010)
- TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus. (2010)
- TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis. (2010)
- Toll-like receptor gene polymorphisms and preeclampsia risk: a case-control study and data synthesis. (2010)
- Toll-like receptor signaling and pre-eclampsia. (2010)
- Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia. (2010)
- Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood. (2009)
- Epidemiology of asthma: risk factors for development. (2009)
- Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency. (2009)
- Potential Sources of Phthalate Exposure in a Vancouver, BC Birth Cohort at Three Months of Age (2009)
Epidemiology, 20, S72 - Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: results of a Canadian multicenter, prospective inception cohort study. (2009)
- Primary immunodeficiency diseases: a practical guide for clinicians. (2009)
- Relative CD4 lymphopenia and a skewed memory phenotype are the main immunologic abnormalities in a child with Omenn syndrome due to homozygous RAG1-C2633T hypomorphic mutation. (2009)
- Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection. (2008)
- Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease. (2008)
- Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevance. (2007)
- Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection. (2007)
- Recurrent systemic pneumococcal disease and IRAK4 deficiency. (2007)
- Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage. (2007)
- Detection of a novel nonsense mutation in the interleukin 2 receptor gamma gene causing X-linked severe combined immunodeficiency. (2006)
- Detection of a novel nonsense mutation in the interleukin 2 receptor γ gene causing X-linked severe combined immunodeficiency [2] (2006)
Annals of Allergy, Asthma and Immunology, 96 (4) - IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells. (2006)
- Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. (2006)
- Old challenges and new directions in pediatric rheumatology (2006)
Journal of Rheumatology, 33 (1), 173-184 - Old challenges and new directions in pediatric rheumatology. (2006)
Journal of Rheumatology, 33 (1), 173-184 - Questions and answers on immunization (2006)
Paediatrics and Child Health, 11 (2) - Questions and answers on immunization. (2006)
Paediatrics and Child Health, 11 (2) - Towards subtlety: understanding the role of Toll-like receptor signaling in susceptibility to human infections. (2006)
- Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. (2005)
- Primary immune deficiencies presenting in adults: seven years of experience from Iran. (2005)
- Adverse reactions to vitamin B12 injections due to benzyl alcohol sensitivity: successful treatment with intranasal cyanocobalamin. (2004)
- Antibiotic desensitization for the allergic patient: 5 years of experience and practice. (2004)
- The Wiskott-Aldrich syndrome. (2004)
- Churg-Strauss syndrome in a 7-year-old receiving montelukast and inhaled corticosteroids [1] (2003)
Annals of Allergy, Asthma and Immunology, 90 (2) - Churg-Strauss syndrome in a 7-year-old receiving montelukast and inhaled corticosteroids. (2003)
- Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. (2003)
- Rituximab therapy for multisystem autoimmune diseases in pediatric patients. (2003)
- Atopic diseases of childhood. (2001)
- Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. (2001)
- IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. (2001)
- Fas ligand-transfected myoblasts and islet cell transplantation. (2000)
- Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of TH1 and TH2 cytokine phenotype. (2000)
- Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of Th1 and Th2 cytokine phenotype1 (2000)
Transplantation, 70 (11 SU), 1641-1649 - Direct allorecognition: a mechanism in intrathymic tolerance induction. (1999)
- Immunobiology of solid organ transplantation (1999)
International Surgery, 84 (4), 279-290 - Immunobiology of solid organ transplantation. (1999)
- Islet allografts: rejection and tolerance induction. (1999)
- Mechanisms of tolerance induction after intrathymic islet injection: Determination of the fate of alloreactive thymocytes (1999)
Transplantation, 68 (1), 30-39 - Mechanisms of tolerance induction after intrathymic islet injection: determination of the fate of alloreactive thymocytes. (1999)
Transplantation, 68 (1), 30-39 - New insights on the mechanisms of acquired intrathymic tolerance (1999)
Current Opinion in Organ Transplantation, 4 (1), 50 - The visualization of T cell responses. (1999)
- Changes in myoplasmic sodium concentration during exposure to lactate in perfused rat heart (1994)
Cardiovascular Research, 28 (7), 987-993 - Changes in myoplasmic sodium concentration during exposure to lactate in perfused rat heart. (1994)
Cardiovascular Research, 28 (7), 987-993 - Intracellular Calcium and Myocardial Function During Ischemia (1993)
Interactive Phenomena in the Cardiac System, , 19--29
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