Matthias Goerges
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Biography
Matthias Görges is a Principal Investigator at the Research Institute, BC Children’s Hospital, where he co-leads the Clinical & Community Data, Analytics & Informatics group. He is a biomedical engineer with extensive clinical research experience, and an Associate Professor (Partner) in the Anesthesiology, Pharmacology & Therapeutics department at the University of British Columbia. As part of an inter-disciplinary team of engineers, computer scientists, and health care providers, he is involved in a wide range of projects focusing on the development and application of new technologies in the pediatric anesthesia and intensive care setting. His research interests are patient monitoring alarms, medical displays, decision support systems, mobile health applications, and data integration/communication platforms. Matthias’ goal is to extract clinically-useful information from vital signs and other clinical data, and to transform these data into information for better, more timely, and more efficient decision-making by clinicians.
Research Methodology
Recruitment
The introduction of information technology in medicine has enabled a transformational change in recent decades. The coronavirus pandemic further accelerated the introduction of virtual care and digital health solutions. Thus, most of my work focuses on designing, implementing, and evaluating ways that leverage technology to improve patient-relevant outcomes.
Clinical context is essential, as understanding the real-world setting where technical innovations are applied is crucial in any engineering discipline. I collaborate with medical experts, including nurses and physicians across several disciplines, engineers, data scientists, and patients and their families, to solve real-world problems. I believe it is essential to appreciate a) that technology supports and enables people, b) we need to integrate data from a wide variety of sources to generate meaningful information to guide decision-making, c) good usability is vital to workflow, and d) high levels of situational awareness are required to ensure patient safety.
My research program focuses on two key objectives:
- Digital health platforms: Develop a research data integration and exchange platform that leverages data from multiple sources, including patient-generated health data and patient-reported outcomes. It will enable (future) linking against electronic medical record data.
- Applications for predictive analytics: Design and implement outcome prediction pipelines that integrate and analyze clinical, patient-provided, and physiological data and create risk stratification models using statistical and machine learning techniques. This is primarily focusing on pediatric anesthesia and pediatric critical care.
Previously, I also worked on a) data displays for clinical decision support, b) vital signs collection infrastructure, and c) closed-loop control of anesthesia.
I consider trainees with biomedical engineering or clinical informatics backgrounds, as my program focuses on predictive analytics and digital health applications in Biomedical Engineering. I occasionally recruit trainees in Experimental Medicine for digital health research projects. Pharmacology is too far from my research interests and core training; therefore, I don't recruit Pharmacology students.
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Background: Type 1 diabetes (T1D) is associated with various psychological struggles, making the management of this condition even more challenging. Integrating digitally enabled peer support interventions into diabetes care may improve mental health outcomes, such as diabetes distress. Objective: The objectives of this study are three-fold: (1) to examine the impact of digitally enabled peer support interventions on mental health outcomes in people living with type 1 diabetes, (2) to explore the mental health support needs of adolescents with T1D, and (3) to elicit feedback for translating REACHOUT, a mobile app originally designed to deliver peer-led mental health support to T1D adults, to meet the unique needs of adolescents with T1D.Methods: For the first objective, we conducted a comprehensive systematic review of the literature on the impact of digitally enabled peer support platforms on mental health outcomes for individuals living with T1D. For the second and third objectives, we utilized focus groups to explore the mental health support needs of adolescents with T1D (from the perspective of adolescents and their parents) and to determine preferences for translating REACHOUT to NexGEN. Results: In the systematic review, out of 3,623 abstracts screened, 34 studies underwent full-text evaluation, and nine were selected for synthesis. Of these, three showed significant reductions in diabetes distress, and two reported improvements in depression. Key factors linked to these outcomes included participatory intervention development, diabetes education, longer duration, theory-based frameworks, and peer mentor involvement.Participants in the focus group were ten adolescents (16 ± 1 years, 80% female) and ten parents (51 ± 7 years, 90% female). Four core themes (with subthemes) emerged, including 1) Experience: Navigating adolescence with T1D; 2) Empowerment: Support systems that enable better management of their T1D; 3) Obstacles: Societal barriers that affect adolescent’s T1D management; and 4) Innovation: Adolescent-driven preferences for virtual peer support platforms. Conclusion: Understanding T1D adolescents' specific support needs is crucial for addressing their emotional and social challenges. Involving them and their parents in tailoring NexGEN to their diabetes management and developmental needs is key. Future research should pilot NexGEN to assess its feasibility and acceptability before evaluative studies.
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Publications
- Blood pressure nomograms for children undergoing general anesthesia, stratified by age and anesthetic type, using data from a retrospective cohort at a tertiary pediatric center (2022)
Journal of Clinical Monitoring and Computing, - Effectiveness of Mobile Apps in Promoting Healthy Behavior Changes and Preventing Obesity in Children: Systematic Review (2022)
JMIR Pediatrics and Parenting, 5 (1), e34967 - Empowering Patients Through Virtual Care Delivery: Qualitative Study With Micropractice Clinic Patients and Health Care Providers (2022)
JMIR Formative Research, - Has Virtual Care Arrived? A Survey of Rural Canadian Providers During the Early Stages of the COVID-19 Pandemic (2022)
Health Services Insights, - Identification of Requirements for a Postoperative Pediatric Pain Risk Communication Tool: Focus Group Study With Clinicians and Family Members (2022)
JMIR Pediatrics and Parenting, - A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2 (2021)
JCI Insight, - An Artificial Neural Network–Based Pediatric Mortality Risk Score: Development and Performance Evaluation Using Data From a Large North American Registry (2021)
JMIR Medical Informatics, 9 (8), e24079 - Anesthesia in the modern world of apps and technology: Implications and impact on wellness (2021)
Pediatric Anesthesia, - Association of dexmedetomidine with recovery room and hospital discharge times: A retrospective cohort analysis (2021)
Pediatric Anesthesia, 31 (11), 1170--1178 - Characteristics and Timing of Mortality in Children Dying With Infections in North American PICUs (2021)
Pediatric Critical Care Medicine, Publi - Derivation and internal validation of a data-driven prediction model to guide frontline health workers in triaging children under-five in Nairobi, Kenya (2021)
Wellcome Open Research, 4, 121 - Effect of ketamine on the NeuroSENSE WAVCNS during propofol anesthesia; a randomized feasibility trial (2021)
Journal of Clinical Monitoring and Computing, 35 (3), 557--567 - News Article Portrayal of Virtual Care for Health Care Delivery in the First 7 Months of the COVID-19 Pandemic (2021)
Telemedicine Reports, 2 (1), 108--117 - Perceptions of Personal Health Records in Rural Primary Health Clinics in Canada – Patient Perspectives (2021)
Studies in Health Technology and Informatics, - Prediction Model Performance With Different Imputation Strategies: A Simulation Study Using a North American ICU Registry. (2021)
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, - Preferred Functions of Personal Health Records in Rural Primary Health Clinics in Canada: Health Care Team Perspectives. (2021)
Applied clinical informatics, - The effect of intraoperative lidocaine infusion on postoperative opioid consumption in adolescents undergoing posterior spinal instrumentation and fusion for idiopathic scoliosis (2021)
The Spine Journal, 21 (7), 1047--1048 - The effect of ketamine on depth of hypnosis indices during total intravenous anesthesia—a comparative study using a novel electroencephalography case replay system (2021)
Journal of Clinical Monitoring and Computing, - The Effect of Low-Dose Intraoperative Ketamine on Closed-Loop-Controlled General Anesthesia: A Randomized Controlled Equivalence Trial (2021)
Anesthesia & Analgesia, - Antibody reactivity against SARS-CoV-2 in adults from the Vancouver metropolitan area, Canada (2020)
- Augmented intelligence in pediatric anesthesia and pediatric critical care (2020)
Current Opinion in Anaesthesiology, , 1 - Derivation and internal validation of a data-driven prediction model to guide frontline health workers in triaging children under-five in Nairobi, Kenya (2020)
Wellcome Open Research, - Evaluating NeuroSENSE for assessing depth of hypnosis during desflurane anesthesia: an adaptive, randomized-controlled trial (2020)
Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 67 (3), 324--335 - Evaluation of a digital triage platform in Uganda: A quality improvement initiative to reduce the time to antibiotic administration (2020)
PLOS ONE, - Feasibility of Using a Single Heart Rate–Based Measure for Real-time Feedback in a Voluntary Deep Breathing App for Children: Data Collection and Algorithm Development (2020)
JMIR Perioperative Medicine, - Grappling With Real-Time Diagnosis and Public Health Surveillance in Sepsis (2020)
Pediatric Critical Care Medicine, - Intravenous cannula placement in children for induction of general anesthesia: Prospective audit and identification of success factors (2020)
Pediatric Anesthesia, 30 (8), 874--884 - Reducing preoperative anxiety with Child Life preparation prior to intravenous induction of anesthesia: A randomized controlled trial (2020)
Pediatric Anesthesia, - The Effect of Carbetocin Dose on Transmural Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery Under Spinal Anesthesia (2020)
Anesthesia & Analgesia, , 1 - What You Need to Know Before Implementing a Clinical Research Data Warehouse: Comparative Review of Integrated Data Repositories in Health Care Institutions (2020)
JMIR Formative Research, - Zero-heat-flux core temperature monitoring system: an observational secondary analysis to evaluate agreement with naso-/oropharyngeal probe during anesthesia (2020)
Journal of Clinical Monitoring and Computing, 34 (5), 1121--1129 - A Postoperative Pain Management Mobile App (Panda) for Children at Home After Discharge: Usability and Feasibility (2019)
JMIR Perioperative Medicine, - An Algorithm for Early Detection of Sepsis Using Traditional Statistical Regression Modeling (2019)
Computing in Cardiology, 2019- - Derivation and internal validation of a data-driven prediction model to guide frontline health workers in triaging children under-five in Nairobi, Kenya (2019)
Wellcome Open Research, 4, 121 - Derivation and internal validation of a data-driven prediction model to guide frontline health workers in triaging children under-five in Nairobi, Kenya [version 1; peer review: awaiting peer review] (2019)
- Development and Implementation of the Portable Operating Room Tracker App With Vital Signs Streaming Infrastructure: Operational Feasibility Study (2019)
JMIR Perioperative Medicine, 2 (2), e13559 - Effects of Dexmedetomidine on Blood Glucose and Serum Potassium Levels in Children Undergoing General Anesthesia: A Secondary Analysis of Safety Endpoints During a Randomized Controlled Trial. (2019)
Anesthesia and analgesia, - Effects of Dexmedetomidine on Myocardial Repolarization in Children Undergoing General Anesthesia: A Randomized Controlled Trial. (2019)
Anesthesia and analgesia, - Feasibility of Automated Vital Sign Instability Detection in Children Admitted to the Pediatric Intensive Care Unit (2019)
Computing in Cardiology, 2019- - Human Computer Interaction Design for Mobile Devices Based on a Smart Healthcare Architecture (2019)
Advances in Computers and Software Engineering: Reviews, , 99--132 - Human Computer Interaction Design for Mobile Devices Based on a Smart Healthcare Architecture (2019)
CoRR, abs/1 - Integrating intraoperative physiology data into outcome analysis for the ACS Pediatric National Surgical Quality Improvement Program (2019)
Pediatric Anesthesia, 29 (1), 27--37 - Optimizing robust PID control of propofol anesthesia for children; design and clinical evaluation (2019)
IEEE Transactions on Biomedical Engineering, , 1--1 - Optimizing Robust PID Control of Propofol Anesthesia for Children: Design and Clinical Evaluation (2019)
IEEE Transactions on Biomedical Engineering, 66 (10), 2918--2923 - Universal Risk Scores and Local Relevance (2019)
Pediatric Critical Care Medicine, 20 (8), 790--792 - Clinician-driven design of VitalPAD – an intelligent monitoring and communication device to improve patient safety in the Intensive Care Unit (2018)
IEEE Journal of Translational Engineering in Health and Medicine, , 1--1 - Data Access and Usage Practices Across a Cohort of Researchers at a Large Tertiary Pediatric Hospital: Qualitative Survey Study (2018)
JMIR Medical Informatics, - Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial (2018)
Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 65 (9), 1029--1040 - External Validation of the “Quick” Pediatric Logistic Organ Dysfunction-2 Score Using a Large North American Cohort of Critically Ill Children With Suspected Infection (2018)
Pediatric Critical Care Medicine, , 1 - Feasibility of continuous sedation monitoring in critically ill intensive care unit patients using the NeuroSENSE WAVCNS index (2018)
Journal of Clinical Monitoring and Computing, 32 (6), 1081--1091 - In-hospital usability and feasibility evaluation of Panda, an app for the management of pain in children at home (2018)
Pediatric Anesthesia, - Mortality Risk Using a Pediatric Quick Sequential (Sepsis-Related) Organ Failure Assessment Varies With Vital Sign Thresholds (2018)
Pediatric Critical Care Medicine, , 1 - Closed-Loop Control of Total Intravenous Anesthesia During Significant Intraoperative Blood Loss (2017)
A & A Case Reports, , 1 - Design and Evaluation of a Closed-Loop Anesthesia System With Robust Control and Safety System (2017)
Anesthesia & Analgesia, , 1 - In Response (2017)
Anesthesia & Analgesia, 124 (5), 1735--1736 - Sequential allocation trial design in anesthesia: an introduction to methods, modeling, and clinical applications (2017)
Pediatric Anesthesia, 27 (3), 240--247 - Using physiological monitoring data for performance feedback: an initiative using thermoregulation metrics (2017)
Canadian Journal of Anesthesia/Journal canadien d'anesthésie, - A Procedural Electroencephalogram Simulator for Evaluation of Anesthesia Monitors (2016)
Anesthesia & Analgesia, , 1 - An Ethnographic Observational Study to Evaluate and Optimize the Use of Respiratory Acoustic Monitoring in Children Receiving Postoperative Opioid Infusions (2016)
Anesthesia & Analgesia, 122 (4), 1132--1140 - Developing an objective method for analyzing vital signs changes in neonates during general anesthesia (2016)
Pediatric Anesthesia, - Preoperative warming and undesired surgical and anesthesia outcomes in pediatric spinal surgery-a retrospective cohort study (2016)
Pediatric Anesthesia, - Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study (2015)
Pediatric Anesthesia, 25 (12), 1287--1293 - A Scheme-based Closed-Loop Anesthesia System (2014)
- Development of mHealth Applications for Pre-Eclampsia Triage (2014)
IEEE J. Biomed. Health Inform., 18 (6), 1857--1864 - Dexmedetomidine and hydromorphone: A novel pain management strategy for the oncology ward setting during anti-GD2 immunotherapy for high-risk neuroblastoma in children. (2014)
- Identifying a rapid bolus dose of dexmedetomidine (ED50) with acceptable hemodynamic outcomes in children. (2014)
- No BP During NIBP (2014)
- Using machine-to-machine / “Internet of Things” communication to simplify medical device information exchange (2014)
2014 International Conference on the Internet of Things (IOT), - A retrospective audit to examine the effectiveness of preoperative warming on hypothermia in spine deformity surgery patients. (2013)
- An Evaluation of an Expert System for Detecting Critical Events During Anesthesia in a Human Patient Simulator (2013)
Anesthesia & Analgesia, 117 (2), 380--391 - Changes in cardiac index and blood pressure on positioning children prone for scoliosis surgery. (2013)
- Evaluation of the effect of information integration in displays for ICU nurses on situation awareness and task completion time: A prospective randomized controlled study. (2013)
- Experience report: functional programming of mHealth applications (2013)
- Mobile Patient Monitoring for the Pediatric Intensive Care Unit: Work Domain Analysis and Rapid Prototyping Results (2013)
- Evaluation of an integrated intensive care unit monitoring display by critical care fellow physicians. (2012)
- ICU nurses' evaluations of integrated information displays on user satisfaction and perceived mental workload. (2012)
- Intensive care unit nurses' information needs and recommendations for integrated displays to improve nurses' situation awareness. (2012)
- University of Queensland Vital Signs Dataset (2012)
Anesthesia & Analgesia, 114 (3), 584--589 - A Far-View Intensive Care Unit Monitoring Display Enables Faster Triage (2011)
Dimensions of Critical Care Nursing, 30 (4), 206--217 - Medical device alarms (2011)
Biomedizinische Technik/Biomedical Engineering, 56 (2), 73--83 - A tool predicting future mean arterial blood pressure values improves the titration of vasoactive drugs. (2010)
- Evaluation of an Ambient Color-Coded Display to Communicate Changes in the Patient’s Condition to ICU Nurses and Improve the Therapeutic Environment (2010)
- Signal processing, human factors, and modelling to support bedside care in the intensive care unit (2010)
- Improving alarm performance in the medical intensive care unit using delays and clinical context. (2009)
- Evaluations of physiological monitoring displays: a systematic review. (2008)
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