Wei Zhang
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Work productivity loss measurement;
Economic evaluation of health interventions
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Theses completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest theses.
The objectives of this thesis were to: (1) examine the sex/gender-specific impacts that employment status change (employment transitions, ETs) have on body weight and waist circumference (WC) changes in middle- and older-age adults and (2) assess the contribution of changes in health behaviours (HBs: sleep duration and quality, smoking status, alcohol consumption, and physical activity) in the association between ETs and anthropometric changes.Chapter 1: Eight bibliometric databases were systematically searched, with citations followed up. Twelve studies were included. All studies examined retirement but reported mixed results. Retirement either led to weight gain or did not alter weight compared to non-retirement. Occupation type modified the association: weight gain was more commonly reported among retirees from physically demanding occupations. Two included studies also examined job-loss and results were also mixed. Key confounders and commonly studied HBs were identified.Chapter 2 & 3: Two waves of data from the Canadian Longitudinal Study on Aging were used to classify 10,117 working women and men into three ET groups: stayed working, entered retirement, and stopped working. The outcomes were change in weight and WC on continuous scales, and change as categories (≥5% gain, ≥5% loss, no change). Multivariable linear and multinomial logistic regressions were adjusted for confounders and HBs.Multivariable linear regression models showed that weight changes did not differ across ETs in women, although changes in WC showed different directions across ET. By contrast, men who entered retirement lost more weight and had greater reductions in WC relative to men who stayed working (-0.59 kg, [95% CI: -1.11, -0.08] and -0.83 cm, [95% CI: -1.46, -0.20]). Final multinomial logistic regression models did not show significant associations; however, the direction of the effects remained. In models that included HB change variables, estimates were not attenuated. Retirement may result in small amounts of weight loss in middle-aged and older Canadian men. Work stoppage appears to lead to more WC increases in women, but the evidence is uncertain. Contrary to hypotheses that place HBs along the pathway between ETs and anthropometric change, the findings from the empirical study suggest that they are independent risk factors instead.
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This study aimed to: (a) adapt the previously validated Valuation of Lost Productivity (VOLP) questionnaire for people with health problems, to a caregiver version to measure work productivity loss associated with caregiving responsibilities, (b) evaluate measurement feasibility and validity of an online version of the caregiver VOLP questionnaire, and (c) compare two caregiver populations based on whether they worked from home.A mixed methods design was utilized. Qualitative methods were used for VOLP adaptation and online conversion. Quantitative methods were used to evaluate feasibility and validity of the online VOLP and compare the two caregiver groups. The Work Productivity and Activity Impairment (WPAI) questionnaire for caregivers was included to compare its outcomes and their correlations with VOLP outcomes.When adapting the VOLP for caregivers, our qualitative analysis showed the importance of adding three major components: caregiving time, work productivity loss related to volunteer activities and caregivers’ lost job opportunities. A total of 382 caregivers who completed online survey were included in our final quantitative analysis. We found small Spearman rank correlations between VOLP and WPAI, observing a larger correlation between absenteeism [r = 0.49 (95% confidence interval: 0.37–0.60)] than presenteeism [r = 0.36 (0.24–0.47)]. Correlations between VOLP outcomes and total caregiving hours were larger for absenteeism [r = 0.38 (0.27–0.47)] than presenteeism [r = 0.22 (0.10–0.34)]. Correlations between WPAI outcomes and total caregiving hours were smaller for absenteeism [r = 0.27 (0.15–0.38)] than presenteeism [r = 0.35 (0.23–0.46)].When comparing caregivers who are working from home and those not working from home, differences in education, occupations and caregiver health status were observed. The VOLP absenteeism and presenteeism outcomes were significantly higher in caregivers working from home than caregivers not working from home, with small effect sizes from 0.16 to 0.19. This was not the case with the WPAI outcomes.The study provides evidence of the feasibility and preliminary validity evidence of the adapted VOLP caregiver questionnaire in measuring work productivity loss due to caregiving responsibilities, when compared with the results for WPAI and results from the previous patient-VOLP validation study.
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Publications
- Influenza vaccination for HIV-positive people: Systematic review and network meta-analysis (2018)
Vaccine, - The association between chronic conditions and non-agricultural work productivity loss among the middle-aged Chinese population (2018)
Journal of occupational and environmental medicine, - Do Biologic Therapies for Rheumatoid Arthritis Offset Treatment-Related Resource Utilization and Cost? A Review of the Literature and an Instrumental Variable Analysis (2017)
Current rheumatology reports, - The impact of price-cap regulations on market entry by generic pharmaceutical firms (2017)
Expert Review of Pharmacoeconomics & Outcomes Research, 17 (2), 231-238 - Valuing productivity loss due to absenteeism: firm-level evidence from a Canadian linked employer-employee survey. (2017)
Health economics review, 7 (1), 3 - Impact of etanercept tapering on work productivity in patients with early rheumatoid arthritis: results from the PRIZE study. (2016)
RMD open, 2 (2), e000222 - The Impact of Price-cap Regulations on Exit by Generic Pharmaceutical Firms (2016)
Medical Care, 54 (9), 884-890 - The relationship between chronic conditions and absenteeism and associated costs in Canada (2016)
Scandinavian Journal of Work Environment & Health, 42 (5), 413-422 - Estimating the monetary value of the annual productivity gained in patients with early rheumatoid arthritis receiving etanercept plus methotrexate: interim results from the PRIZE study. (2015)
RMD open, 1 (1), e000042 - Illness related wage and productivity losses: Valuing 'presenteeism' (2015)
Social Science & Medicine, 147, 62-71 - Systematic Review of Cost-Effectiveness Analyses of Treatments for Psoriasis (2015)
Pharmacoeconomics, 33 (4), 327-340 - Health-Related Productivity Loss: NICE to Recognize Soon, Good to Discuss Now (2014)
Pharmacoeconomics, 32 (5), 425-427 - The Preventable Burden of Productivity Loss Due to Suboptimal Asthma Control A Population - Based Study (2014)
Chest, 145 (4), 787-793 - The impacts of health insurance on health care utilization among the older people in China (2013)
Social Science & Medicine, 85, 59-65 - An update on the measurement of productivity losses due to rheumatoid diseases (2012)
Best Practice & Research in Clinical Rheumatology, 26 (5), 585-597 - Development of a Composite Questionnaire, the Valuation of Lost Productivity, to Value Productivity Losses: Application in Rheumatoid Arthritis (2012)
Value in Health, 15 (1), 46-54 - Does achieving clinical response prevent work stoppage or work absence among employed patients with early rheumatoid arthritis? (2012)
Rheumatology, 51 (2), 270-274 - Factors associated with absenteeism, presenteeism and activity impairment in patients in the first years of RA (2012)
Rheumatology, 51 (2), 375-384 - Work disability rates in RA. Results from an inception cohort with 24 years follow-up (2012)
Rheumatology, 51 (2), 385-392 - Measuring and valuing productivity loss due to poor health: A critical review (2011)
Social Science & Medicine, 72 (2), 185-192 - Measuring the Impact of Arthritis on Worker Productivity: Perspectives, Methodologic Issues, and Contextual Factors (2011)
Journal of Rheumatology, 38 (8), 1776-1790 - Measuring Time Input Loss Among Patients With Rheumatoid Arthritis Validity and Reliability of the Valuation of Lost Productivity Questionnaire (2011)
Journal of Occupational and Environmental Medicine, 53 (5), 530-536 - The economic burden of rheumatoid arthritis: beyond health care costs (2011)
Clinical Rheumatology, 30, S25-S32 - Cost-effectiveness of Anticipatory and Preventive multidisciplinary Team Care for complex patients Evidence from a randomized controlled trial (2010)
Canadian Family Physician, 56 (1), E20-E29 - Obesity and overweight in Canada: an updated cost-of-illness study (2010)
Obesity Reviews, 11 (1), 31-40 - Productivity Loss Due to Presenteeism Among Patients with Arthritis: Estimates from 4 Instruments (2010)
Journal of Rheumatology, 37 (9), 1805-1814 - The Work Instability Scale for Rheumatoid Arthritis (RA-WIS): Does it work in osteoarthritis? (2010)
Quality of Life Research, 19 (7), 1057-1068 - The Work Instability Scale for Rheumatoid Arthritis Predicts Arthritis-Related Work Transitions Within 12 Months (2010)
Arthritis Care & Research, 62 (11), 1578-1587 - Validity of the work productivity and activity impairment questionnaire - general health version in patients with rheumatoid arthritis (2010)
Arthritis Research & Therapy, 12 (5) - Work Productivity Among Employed Canadians With Arthritis (2010)
Journal of Occupational and Environmental Medicine, 52 (9), 872-877 - Health Insurance and Out-of-Pocket Expenses (2009)
Arthritis & Rheumatism-Arthritis Care & Research, 61 (11), 1467-1469 - Measuring Worker Productivity: Frameworks and Measures (2009)
Journal of Rheumatology, 36 (9), 2100-2109 - Randomized controlled trial of Anticipatory and Preventive multidisciplinary Team Care For complex patients in a community-based primary care setting (2009)
Canadian Family Physician, 55 (12), E76-E85 - The effect of etanercept on work productivity in patients with early active rheumatoid arthritis: results from the COMET study (2009)
Rheumatology, 48 (10), 1283-1289 - The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis (2009)
Bmc Public Health, 9 - Short-term influence of adalimumab on work productivity outcomes in patients with rheumatoid arthritis (2008)
Journal of Rheumatology, 35 (9), 1729-1736 - Patient, informal caregiver and care provider acceptance of a hospital in the home program in Ontario, Canada (2007)
Bmc Health Services Research, 7 - The costs of preventing the spread of respiratory infection in family physician offices: a threshold analysis (2007)
Bmc Health Services Research, 7
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