![](https://www.grad.ubc.ca/sites/default/files/styles/card_vertical_767/public/students/brett_hathaway.jpg?itok=PAhB4VDe&c=7973ebc02b0cc7bc2820f793b205e1fc)
Brett Hathaway
Doctor of Philosophy in Neuroscience (PhD)
Investigating the neurological and behavioural mechanisms of risky decision making and cognitive inflexibility induced by reward-paired cues
Ranked among the world’s top medical schools with the fifth-largest MD enrollment in North America, the UBC Faculty of Medicine is a leader in both the science and the practice of medicine. Across British Columbia, more than 12,000 faculty and staff are training the next generation of doctors, health care professionals, and medical researchers, making remarkable discoveries to help create the pathways to better health for our communities at home and around the world.
The UBC Faculty of Medicine offers a diverse array of training opportunities including cutting-edge research experiences in the biosciences, globally recognized population health education, quality health professional training, as well as several certificate and online training options. The Faculty of Medicine is home to more than 1,700 graduate students housed in 20 graduate programs (14 of which offer doctoral research options). Year after year, research excellence in the Faculty of Medicine is supported by investment from funding sources here at home and around the globe, receiving approximately more than $1.8B in total research funding since 2016.
We value our trainees and the creative input they have to scholarly activities at UBC. Our priority is to enable their maximum potential through flexible opportunities that provide a breadth of experiences tailored to their own individual career objectives. We maintain high standards of excellence, and work to create a community of intellectually and socially engaged scholars that work collaboratively with each other, the university, and the world, with the overarching goal of promoting the health of individuals and communities.
Most Faculty research is conducted under the auspices of 23 centres and institutes that are part of UBC or affiliated with it, in collaboration with our health partners.
UBC Faculty of Medicine provides innovative educational and research programs in the areas of health and life sciences through an integrated and province-wide delivery model in facilities at locations throughout British Columbia.
The Life Sciences Centre is the largest building on the UBC Vancouver campus. Completed in 2004, the $125 million, 52,165 sq metres building was built to accommodate the distributed medical educational program and the Life Sciences Institute.
The Djavad Mowafaghian Centre for Brain Health (DMCBH), a partnership between the University of British Columbia and Vancouver Coastal Health, unites under one roof research and clinical expertise in neuroscience, psychiatry and neurology in order to accelerate discovery and translate new knowledge into better treatment and prevention strategies. DMCBH has both laboratory and clinical research areas within the Centre proper and in the UBC Hospital Koerner Pavilion. Our core facilities are essential to ongoing collaboration, teaching, and research.
The BC Children's Hospital Research Institute is it the largest research institute of its kind in Western Canada in terms of people, productivity, funding and size. With more than 350,000 square feet of space, the Institute has both 'wet bench' laboratory and 'dry lab' clinical research areas, and other areas to facilitate particular areas of research and training.
New knowledge and innovation are crucial to successfully identifying, addressing and overcoming the increasingly complex health-related challenges that influence the lives of all of us – in British Columbia, in Canada, and in countries and communities around the globe.
The UBC Faculty of Medicine is recognized nationally and internationally for research innovation that advances knowledge and translates new discoveries to improve the health and well-being of individuals and communities. Research opportunities feature extensive collaborations across other faculties, health institutions and health partners across British Columbia, Canada and internationally.
The Faculty provides and fosters research excellence across the full continuum, from basic science to applied science and then to knowledge implementation, with a focus on precision health; cancer; brain and mental health; heart and lung health; population health; and chronic diseases.
Name | Academic Unit(s) | Research Interests |
---|---|---|
Loewen, Christopher | Department of Cellular & Physiological Sciences | Membranes and Organelles; Lipid Signalling; Lipid Traffic; Membrane Contact Sites; Genetic Networks; Systems Biology; Super Resolution Microscopy; Cell polarity; Endoplasmic Reticulum; Golgi; Membrane Diffusion Barriers; Cell Biology; Autism; Amyotrophic Lateral Sclerosis (ALS); Cancer Cell Metabolism |
Loock, Christine Ann | Department of Pediatrics | Brain, Behaviour & Development; Social Pediatrics; Health Inequities; Child-health medical-home: children/families, integration / patient care / community services; Fetal Alcohol Spectrum Disorders; Pediatric Sleep Disorders |
Loree, Jonathan | Division of Medical Oncology | Cancer; Carcinoid tumors |
Lorincz, Matthew | Department of Medical Genetics | Genetic medicine; Developmental Genetics; genomics; chromatin; Development; Epigenetics; Epigenomics; Gene regulation |
Loucks, Catrina | Department of Pediatrics, Department of Anesthesiology, Pharmacology & Therapeutics | Medical, health and life sciences; Pharmacogenomics; Pain management; Medical Genetics; Model organism genetics; Drug reactions |
Luciani, Dan | Department of Surgery | Cell metabolism; Cell differentiation, proliferation and death; Organelle function; Other basic medicine and life sciences; Diabetes; Pancreatic beta-cell function and failure; Mitochondrial physiology; Lysosomal physiology; Cell calcium signalling; Cell stress signalling; Mechanisms of cell death; autophagy; Cellular senescence; fluorescence microscopy |
Lui, Harvey | Department of Dermatology & Skin Science | lasers; skin disease; psoriasis; dermatology; pigmentary disorders; vitiligo; applied optics; photomedicine; photodynamic therapy, Dermatology, photomedicine, lasers, psoriasis, vitiligo, dermatologic education |
Lunken, Genelle | Department of Pediatrics | Clinical nutrition; Human nutrition and dietetics, n.e.c.; Gastroenterology; Personalised nutrition therapies; Dietary fibre; Inflammatory bowel disease; Gut microbiome; Food additives |
Luo, Honglin | Department of Pathology & Laboratory Medicine | Basic medicine and life sciences; Viral Infections; Cardiomyopathy; Innate immunity; Central Nervous System Inflammatory Diseases; Enteroviral infection and neurodegeneration; Oncolytic virus; Protein quality control in cardiac remodeling; RNA viruses |
Lynn, Francis | Department of Surgery, School of Biomedical Engineering | Diabetes; ß-cell development; ß-cell biology; Human pluripotent stem cells; CRISPR/Cas; transcriptional regulation |
Lyons, Christopher | Department of Ophthalmology & Visual Sciences | Pediatric Ophthalmology; Oculoplastics |
MacHan, Lindsay | Department of Radiology | radiology; infertility; vascular disease |
Mackenzie, Ian | Department of Pathology & Laboratory Medicine | Alzheimer's Disease |
MacLure, Malcolm | Department of Anesthesiology, Pharmacology & Therapeutics | Epidemiology, patient safety, quality control, pharmaceutical sciences, health services research |
Macnab, Andrew | Department of Pediatrics | Developmental Neurosciences, Child Health, Diabetes, Nutrition & Metabolism (Nutrition & Metabolism) |
MacNab, Ying | School of Population and Public Health | Bayesian paradigm, foundations of statistics, space-time statistics, structured statistical models, taxonomic models, item response theory, inductive reasoning, Bayesian burden of disease methodology, Geometics, Health service and population health geoinformation system, and meta-data innovation in medical and health research |
MacNeily, Andrew | Department of Urologic Sciences | Evidence to Innovation; Care of children with urological conditions |
MacVicar, Brian | Department of Psychiatry | Brain Research, epilepsy, astrocyte, glia, dendrites, synapse, imaging, two photon laser scanning microscopy, neurophysiology, Role of calcium, regulation of neurons, cell death |
Madden, Kenneth | Division of Geriatric Medicine | Geriatrics and gerontology; Exercise interventions; Sedentary Behaviour; Syncope; Falls Prevention; Sarcopenia; Machine Learning |
Madhav, Manu | School of Biomedical Engineering | Neurosciences, medical and physiological and health aspects; Cognitive representations in the brain; Place cells; Spatial navigation; Path planning; Control theory; Alzheimer's disease |
Mancini, John | Divisions of Cardiology & Cardiovascular Surgery | Cardiology |
Manges, Amee | School of Population and Public Health | Health sciences; Immunology; Microbiology; Public and population health; Epidemiology; Molecular epidemiology; Public health |
Mannas, Miles | Department of Urologic Sciences | prostate cancer, novel techniques for real-time pathologic tissue analysis utilizing artificial intelligence |
Marinova-Todd, Stefka | School of Audiology and Speech Sciences | bilingualism, second language acquisition, language development, literacy, ESL children, children at risk of language difficulties, language disorders in bilingual children and adults, Second language acquisition; language development and language learning difficulties of bilingual children |
Marra, Marco | Department of Medical Genetics, Michael Smith Laboratories | Genomics; Bioinformatics, n.e.c.; Epigenetics and epigenomics; Genetics, n.e.c.; Cancer genetics; Genetics; Epigenomics; Cancer biology |
This is an incomplete sample of recent publications in chronological order by UBC faculty members with a primary appointment in the Faculty of Medicine.
Year | Citation | Program |
---|---|---|
2023 | Dr. Wells studied how our DNA faces internal obstacles and proposed a model featuring multiple repair pathways that work to tolerate this stress and prevent DNA damage. This work enhances our understanding of genome instability, a feature of cancer development and treatment. | Doctor of Philosophy in Interdisciplinary Oncology (PhD) |
2023 | Dr. Ge developed novel drugs targeting GluN2B-containing NMDA receptors and demonstrated that these drugs improved learning and memory in rat models. This research generated a potential pharmacotherapy for various learning disabilities. | Doctor of Philosophy in Neuroscience (PhD) |
2023 | Dr. Wang investigated how YAP1 gene regulates the differentiation of progenitor cells in the pancreas. He provided new evidence that manipulation of YAP1 expression controls pancreatic size and function during embryogenesis. His research shed light on the future development of cell therapy for type 1/2 diabetes and pancreatic cancer. | Doctor of Philosophy in Cell and Developmental Biology (PhD) |
2023 | Dr. Vaikakkara Chithran's work explores how neural circuits are maintained in the adult nervous system. She demonstrated that axon guidance cues are essential for the survival of adult neurons. Her research also contributed to the development of a novel tauopathy model to study how protein toxicity leads to neurodegeneration and neuronal death. | Doctor of Philosophy in Neuroscience (PhD) |
2023 | Dr. Skinnider used machine learning to identify proteins that physically interact in living tissues. His work revealed how inherited mutations, present in every cell in the body, can cause dysfunction in just a single tissue. | Doctor of Medicine and Doctor of Philosophy (MDPhD) |
2023 | Dr. Sridhar studied regions of close contact between parts of a cell using budding yeast. She studied the role of previously uncharacterized proteins in maintaining steady state levels of lipids at these sites. Similar proteins are present in humans and could have a role in disease biology. | Doctor of Philosophy in Cell and Developmental Biology (PhD) |
2023 | Dr. Eskandari showed that CASPASE-3, which is an enzyme known for its role in mediating cell death, has pro-survival roles in human mammary cells. This research assist us in understanding the mechanisms of cancer cell survival, and can help improve treatments for breast cancer therapy. | Doctor of Philosophy in Medical Genetics (PhD) |
2023 | Dr. Saleem studied home oxygen therapy in interstitial lung disease. He developed a scoring system to predict low blood oxygen, analyzed prescription criteria for oxygen worldwide, identified countries lacking access to oxygen, and determined the costs for this therapy. His research will help identify public health needs related to home oxygen. | Doctor of Philosophy in Experimental Medicine (PhD) |
2023 | Dr. Hasbullah investigated the role of specific gene variants that increases the risk of patients developing heart failure after treatment from certain chemotherapy drugs. His research identified critical biological pathways that can cause this toxicity and demonstrated how drugs that modulate these pathways can prevent this adverse drug reaction. | Doctor of Philosophy in Medical Genetics (PhD) |
2023 | Dr. Kim studied movement disorders in precariously housed and homeless people. He found that substance use and psychosis were differentially associated with movement disorders, and that parkinsonism rapidly increased over time. His research helps increase awareness of movement disorders in at-risk groups, especially during the overdose crisis. | Doctor of Philosophy in Pharmacology (PhD) |